Association patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationMulti-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes
Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Vilar-Ribó L, Xu H, Hatoum A, Johnson E, Pazdernik V, Jinwala Z, Pakala S, Leger B, Niarchou M, Ehinmowo M, Jenkins G, Batzler A, Pendegraft R, Palmer A, Zhou H, Biernacka J, Coombes B, Gelernter J, Xu K, Hancock D, Cox N, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. Nature Human Behaviour 2024, 8: 1177-1193. PMID: 38632388, PMCID: PMC11199106, DOI: 10.1038/s41562-024-01851-6.Peer-Reviewed Original ResearchConceptsTobacco use disorderPotential risk genesMulti-ancestry meta-analysisMultiple health outcomesElectronic health recordsSource of phenotypic informationGenome-wide association studiesUse disorderAscertainment cohortHealth outcomesHealth recordsPrevalent substance use disordersRisk genesIndependent risk lociUK BiobankSubstance use disordersSmoking behaviorMedical outcomesFunctional genomics toolsPsychiatric traitsAssociation studiesRisk lociRisk variantsHeart diseaseGenomic tools