2017
Clinicopathologic and outcome study of sessile serrated adenomas/polyps with serrated versus intestinal dysplasia
Cenaj O, Gibson J, Odze RD. Clinicopathologic and outcome study of sessile serrated adenomas/polyps with serrated versus intestinal dysplasia. Modern Pathology 2017, 31: 633-642. PMID: 29271414, DOI: 10.1038/modpathol.2017.169.Peer-Reviewed Original ResearchConceptsSessile serrated adenomas/polypsSerrated adenomas/polypsAdenomas/polypsIntestinal dysplasiaConventional adenomasSerrated dysplasiaPrevalence of adenocarcinomaType of dysplasiaHigh-grade lesionsDysplasia-carcinoma sequenceLow-grade dysplasiaNeoplastic precursor lesionsHigh rateDysplasia subtypeControl patientsPathologic featuresMean ageMicrosatellite unstable cancersBiologic featuresInvasive carcinomaPrecursor lesionsNeoplastic lesionsPrevalence ratesOutcome studiesPatients
2016
Pathology of premalignant colorectal neoplasia
Gibson JA, Odze RD. Pathology of premalignant colorectal neoplasia. Digestive Endoscopy 2016, 28: 312-323. PMID: 26861656, DOI: 10.1111/den.12633.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsColorectal cancerPrecursor lesionsColorectal carcinogenesisMolecular featuresManagement of patientsNeoplastic precursor lesionsEpithelial precursor lesionsScreening colonoscopyColorectal neoplasiaColorectal carcinomaColorectal polypsColon cancerPersonalized treatmentOncological diseasesCancerEarly detectionMolecular pathwaysPatientsLesionsEarly phasePresent reviewCarcinogenesisSignificant changesColonoscopyCarcinoma
2015
Clinical, pathologic, and outcome study of hyperplastic and sessile serrated polyps in inflammatory bowel disease
Shen J, Gibson JA, Schulte S, Khurana H, Farraye FA, Levine J, Burakoff R, Cerda S, Qazi T, Hamilton M, Srivastava A, Odze RD. Clinical, pathologic, and outcome study of hyperplastic and sessile serrated polyps in inflammatory bowel disease. Human Pathology 2015, 46: 1548-1556. PMID: 26297256, DOI: 10.1016/j.humpath.2015.06.019.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseNeoplastic lesionsHyperplastic polypsFlat dysplasiaIBD patientsBowel diseaseAdenoma-like dysplasiaTraditional serrated adenomasSessile serrated polypsAverage followSurgical resectionClinicopathological featuresColon resectionSporadic adenomasSerrated polypsLower riskSerrated pathwayPatientsSerrated adenomasLesionsDysplasiaAdenoma/AdenocarcinomaResectionAdenomas
2011
MUC Expression in Hyperplastic and Serrated Colonic Polyps
Gibson JA, Hahn HP, Shahsafaei A, Odze RD. MUC Expression in Hyperplastic and Serrated Colonic Polyps. The American Journal Of Surgical Pathology 2011, 35: 742-749. PMID: 21490447, DOI: 10.1097/pas.0b013e31821537a2.Peer-Reviewed Original ResearchConceptsSSA/PExpression of MUC6Hyperplastic polypsSerrated polypsSSA/PsPolyp groupRight colonMUC expressionColonic polypsSerrated colonic polypsSessile serrated adenomas/polypsSerrated adenomas/polypsTraditional serrated adenomasGoblet cell typeProgression of malignancyAdenomas/polypsIntensity of stainingDifferent anatomic locationsMicrovesicular typeSerrated carcinogenesisDifferential diagnosisMUC6 expressionAnatomic locationSerrated pathwaySerrated adenomas
2009
Mucosal Schwann Cell “Hamartoma”
Gibson JA, Hornick JL. Mucosal Schwann Cell “Hamartoma”. The American Journal Of Surgical Pathology 2009, 33: 781-787. PMID: 19065103, DOI: 10.1097/pas.0b013e31818dd6ca.Peer-Reviewed Original ResearchMeSH KeywordsActinsAgedAged, 80 and overAntigens, CD34Cell DifferentiationCell ProliferationClaudin-1Colonic PolypsColonoscopyColorectal NeoplasmsDiagnosis, DifferentialFemaleGlial Fibrillary Acidic ProteinHamartomaHumansImmunohistochemistryIncidental FindingsIntestinal MucosaMaleMembrane ProteinsMiddle AgedMucin-1Neurofibromatosis 1Neurofilament ProteinsNeuromaProto-Oncogene Proteins c-kitS100 ProteinsSchwann CellsConceptsLamina propriaHistologic featuresGanglion cellsSchwann cellsColorectal polypsNF1 patientsNeurofilament proteinDense eosinophilic cytoplasmGlial fibrillary acidic proteinSolitary colorectal polypsSimilar histologic featuresBland spindle cellsIndistinct cell bordersType 1 neurofibromatosisEpithelial membrane antigenFibrillary acidic proteinSchwann cell proliferationSmooth muscle actinUniform bland spindle cellsRare axonsMucosal biopsiesPositive axonsImmunohistochemical featuresNeural lesionsIntralesional heterogeneity