2019
Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms
Yan J, Bassler B. Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms. Cell Host & Microbe 2019, 26: 15-21. PMID: 31295420, PMCID: PMC6629468, DOI: 10.1016/j.chom.2019.06.002.Peer-Reviewed Original ResearchConceptsSurface-associated bacterial communitiesSingle-cell resolutionBiofilm formation processBiofilm resilienceBacterial communitiesPersister cellsAntibiotic toleranceBacterial toleranceBacterial biofilmsBiofilmsBacterial recurrenceToleranceAntibiotic resistanceRecent progressPersistencePhenotypeBiofilm eradicationNew strategyCommunityCellsHarmful role
2016
Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging
Yan J, Sharo AG, Stone HA, Wingreen NS, Bassler BL. Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e5337-e5343. PMID: 27555592, PMCID: PMC5018804, DOI: 10.1073/pnas.1611494113.Peer-Reviewed Original ResearchConceptsV. cholerae biofilmsSingle-cell live imagingSurface-associated bacterial communitiesVibrio cholerae biofilmsSingle-cell technologiesSingle founder cellRod-shaped bacteriaFounder cellsSingle geneBacterial communitiesLive imagingBiofilm architectureBiofilm componentsBiofilm structureCell heterogeneityIndividual cellsMatrix labelingMature biofilmsArt microscopy techniquesCompetition analysisBiofilmsSingle-cell resolution imagingGenesGrowth programCells