Featured Publications
Social evolution of shared biofilm matrix components
Tai J, Mukherjee S, Nero T, Olson R, Tithof J, Nadell C, Yan J. Social evolution of shared biofilm matrix components. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2123469119. PMID: 35771939, PMCID: PMC9271185, DOI: 10.1073/pnas.2123469119.Peer-Reviewed Original ResearchConceptsBiofilm matrix componentsCooperative public goodsMatrix componentsBiofilm formationBiofilm matrix proteinsMatrix productionSocial evolution theoryBiofilm spatial structureCell surface adhesionEvolutionary timescalesCell clustersRelatedness coefficientsBacterial communitiesBiofilm habitatAdhesion proteinsEvolutionary advantageEvolutionary stabilityMatrix proteinsAssociated analysis toolsDiffusible compoundsHost environmentSocial evolutionUbiquitous modeOutstanding questionsProtein
2017
Flow environment and matrix structure interact to determine spatial competition in Pseudomonas aeruginosa biofilms
Nadell CD, Ricaurte D, Yan J, Drescher K, Bassler BL. Flow environment and matrix structure interact to determine spatial competition in Pseudomonas aeruginosa biofilms. ELife 2017, 6: e21855. PMID: 28084994, PMCID: PMC5283829, DOI: 10.7554/elife.21855.Peer-Reviewed Original ResearchConceptsMatrix mutantsWild-type cellsMicrobial communitiesMatrix producersEvolutionary stabilityNon-producing strainsMatrix organizationRelative abundanceExtracellular matrixMatrix secretionMatrix productionMutantsSimple flow regimesInitial frequencyBacteriaNatural environmentBiofilmsPseudomonas aeruginosaAbundanceCompetitive dynamicsPseudomonasSpatial competitionSpatial structureCompetitionPotential explanation