2022
Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity
Chen X, Zhou W, Song R, Liu S, Wang S, Chen Y, Gao C, He C, Xiao J, Zhang L, Wang T, Liu P, Duan K, Cheng Z, Zhang C, Zhang J, Sun Y, Jackson F, Lan F, Liu Y, Xu Y, Wong J, Wang P, Yang H, Xiong Y, Chen T, Li Y, Ye D. Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Science Advances 2022, 8: eabl5220. PMID: 35080973, PMCID: PMC8791617, DOI: 10.1126/sciadv.abl5220.Peer-Reviewed Original ResearchDNA methyltransferasesDNA methylationDe novo DNA methylationMammalian embryonic developmentNovo DNA methylationPRC2 target genesLonger splice isoformsCCAAT/enhancer binding protein αAberrant DNA methylationEnhancer binding protein αDNMT3A activityDNMT3a isoformsDNA substratesEmbryonic developmentSpecific lociTarget genesSplice isoformsDNA-hypomethylating agentN-terminusShort isoformProtein αMethylationFunctional differencesIsoformsMutations
2012
Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein*
Cheng J, Yang Y, Fang J, Xiao J, Zhu T, Chen F, Wang P, Li Z, Yang H, Xu Y. Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein*. Journal Of Biological Chemistry 2012, 288: 1329-1339. PMID: 23161542, PMCID: PMC3543016, DOI: 10.1074/jbc.m112.415398.Peer-Reviewed Original ResearchConceptsTandem Tudor domainHistone H3 lysine 9Plant homeodomainH3 lysine 9Tudor domainHistone methylationLysine 9DNA methylationStructural insightsDNA replication forksCoordinated recognitionImportant epigenetic regulatorsUnmodified histone H3Unmodified H3UHRF1 proteinReplication forksHistone H3Epigenetic regulatorsLys-9Autoubiquitination activityLys-4H3K9me3UHRF1Linker regionBiochemical experiments