2022
MIF is a common genetic determinant of COVID-19 symptomatic infection and severity
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. QJM 2022, 116: 205-212. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorLow-expression MIF alleleCOVID-19 infectionMIF allelesCATT7 alleleHealthy controlsCOVID-19Serum macrophage migration inhibitory factorSymptomatic SARS-CoV-2 infectionHigher serum MIF levelsHigh-expression MIF allelesRetrospective case-control studySARS-CoV-2 infectionFunctional polymorphismsAvailable clinical characteristicsMultinational retrospective studySerum MIF levelsUninfected healthy controlsSymptomatic COVID-19Tertiary medical centerHealthy control subjectsCase-control studyMigration inhibitory factorCoronavirus disease 2019Common functional polymorphisms
2015
Identification of cancer‐related genes and motifs in the human gene regulatory network
Carson M, Gu J, Yu G, Lu H. Identification of cancer‐related genes and motifs in the human gene regulatory network. IET Systems Biology 2015, 9: 128-134. PMID: 26243828, PMCID: PMC8687282, DOI: 10.1049/iet-syb.2014.0058.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceChromosome MappingGene Expression Regulation, NeoplasticGenes, NeoplasmGenetic Predisposition to DiseaseHumansMolecular Sequence DataMultigene FamilyNeoplasmsNucleotide MotifsTranscription Factors