2022
MIF is a common genetic determinant of COVID-19 symptomatic infection and severity
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. QJM 2022, 116: 205-212. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorLow-expression MIF alleleCOVID-19 infectionMIF allelesCATT7 alleleHealthy controlsCOVID-19Serum macrophage migration inhibitory factorSymptomatic SARS-CoV-2 infectionHigher serum MIF levelsHigh-expression MIF allelesRetrospective case-control studySARS-CoV-2 infectionFunctional polymorphismsAvailable clinical characteristicsMultinational retrospective studySerum MIF levelsUninfected healthy controlsSymptomatic COVID-19Tertiary medical centerHealthy control subjectsCase-control studyMigration inhibitory factorCoronavirus disease 2019Common functional polymorphisms
2016
Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma
Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, Zhong N. Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. International Journal Of Molecular Medicine 2016, 38: 446-456. PMID: 27277384, PMCID: PMC4935459, DOI: 10.3892/ijmm.2016.2634.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsthmaCase-Control StudiesChildCytokinesDemographyDown-RegulationErbB ReceptorsEstrogen Receptor alphaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansInflammation MediatorsMaleMicroRNAsNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene MasProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-cblPyroglyphidaeReal-Time Polymerase Chain ReactionRNA, MessengerSyk KinaseUp-RegulationConceptsPediatric asthmaPlasma concentrationsGender-matched healthy controlsCbl proto-oncogeneMite-induced asthmaPeroxisome proliferator-activated receptorInflammatory cytokine pathwaysMicroRNA-22-3pTumor necrosis factorProliferator-activated receptorEnzyme-linked immunosorbentRegulation of CblMiR-22-3pAsthma groupIL-10Asthma attacksHealthy controlsCytokine pathwaysNecrosis factorEstrogen receptorImmune responseESR1 expressionAsthmaControl groupInvolvement of microRNAs