2015
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell 2015, 160: 1222-1232. PMID: 25748653, PMCID: PMC4484787, DOI: 10.1016/j.cell.2015.02.024.Peer-Reviewed Original ResearchConceptsHypothalamic AgRP neuronsAgRP neuronsNeuropeptidergic signalingReceptor signalingFunctional rolePotential therapeutic avenuesAgRP neuron activationStereotypic behaviorFeeding behaviorRepetitive behaviorsSignalingTherapeutic avenuesFood triggersAdult miceNervous systemDecreased anxietyNeuronsMinor effectActivationFood consumptionNeuron activationGoal-directed behaviorSensory informationFlexible goal-directed behaviorDisease
2009
Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain
Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE. Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain. Molecular Therapy 2009, 18: 588-593. PMID: 20010918, PMCID: PMC2839442, DOI: 10.1038/mt.2009.286.Peer-Reviewed Original ResearchConceptsSubstantia nigraPrimate brainCaudate nucleusSerotype 1Central nervous systemProtein-positive cellsAAV serotype 2Long-term transductionNigrostriatal systemClinical trialsPositive cellsNervous systemUnbiased stereologyVector injectionComparable titersNeural cellsBrainTransduction efficiencySerotype 2Vector transduction efficiencyTherapeutic transgenesViral vectorsNigraEnhanced green fluorescent protein (EGFP) reporter geneAAV vectors