2022
Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum
Mitchel K, Bergmann JM, Brent AE, Finkelstein TM, Schindler KA, Holzman MA, Jeannotte L, Mansfield JH. Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum. Frontiers In Cell And Developmental Biology 2022, 10: 806545. PMID: 35557949, PMCID: PMC9086245, DOI: 10.3389/fcell.2022.806545.Peer-Reviewed Original ResearchLateral somitic frontierLateral plate mesodermSkeletal patterningTissue-specific contributionsPlate mesodermEmbryonic precursorsGenetic controlProper developmentHOXA5 expressionEmbryonic sourcesRegulate DevelopmentSkeletal phenotypeConditional deletionEmbryological informationMultiple rolesMesodermSkeletal systemHoxSomitesTheriansPrimordiaAdditive roleRegulatorDeletionMost aspects
2018
HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system
Holzman MA, Bergmann JM, Feldman M, Landry-Truchon K, Jeannotte L, Mansfield JH. HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system. The International Journal Of Developmental Biology 2018, 62: 785-796. PMID: 30604848, PMCID: PMC8783609, DOI: 10.1387/ijdb.180214jm.Peer-Reviewed Original ResearchConceptsLateral plate mesodermHOXA5 expressionSkeletal patterningPlate mesodermNon-cell autonomous functionCell-autonomous roleProtein expressionSatellite cell lineageLineage restrictionGenetic lineagesEmbryonic cellsCell lineagesLateral sclerotomeTissue specificitySomite stageSkeletal developmentLineagesAutonomous roleDirect roleMusculoskeletal morphologyTissue typesMesodermHOXA5SomitesAutonomous functions