2011
Early interventions to prevent mental disorders - learning lessons from the field of psychosis
Moriyama TS, Miguel EC, Leckman J. Early interventions to prevent mental disorders - learning lessons from the field of psychosis. Brazilian Journal Of Psychiatry 2011, 33: s125-s128. PMID: 22286563, DOI: 10.1590/s1516-44462011000600001.Peer-Reviewed Original Research
2007
A Developmental Perspective on the Controversy Surrounding the Use of SSRIs to Treat Pediatric Depression
Leckman JF, King RA. A Developmental Perspective on the Controversy Surrounding the Use of SSRIs to Treat Pediatric Depression. American Journal Of Psychiatry 2007, 164: 1304-1306. PMID: 17728409, DOI: 10.1176/appi.ajp.2007.07050880.Peer-Reviewed Original Research
2006
Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome
Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAdultAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBipolar DisorderChildDepressive DisorderFemaleFollow-Up StudiesHumansIntelligence TestsMaleObsessive-Compulsive DisorderProspective StudiesSchizophreniaSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexTic DisordersTourette SyndromeConceptsTic symptomsTourette syndromeTic severitySymptom severityObsessive-compulsive disorderBaseline clinical measurementsChildhood-onset neuropsychiatric disorderOCD symptomsPercent of patientsProspective cohort studyPercent of subjectsOutpatient specialty clinicsThird of childrenThird of adultsAge 14 yearsStructured clinical evaluationCohort studyClinical courseComplete resolutionClinical evaluationPhonic ticsSpecialty clinicFollow-up interviewObsessive-compulsive symptom severityAverage age
2005
Antidepressant‐Induced Manic Conversion: A Developmentally Informed Synthesis of the Literature
Lim CJ, Leckman JF, Young C, Martin A. Antidepressant‐Induced Manic Conversion: A Developmentally Informed Synthesis of the Literature. International Review Of Neurobiology 2005, 65: 25-52. PMID: 16140052, DOI: 10.1016/s0074-7742(04)65002-1.Peer-Reviewed Original ResearchConceptsAddition of antidepressantsResolution of symptomsAntidepressant-induced maniaSerotonin reuptake inhibitorsMood stabilizer therapyLess nursing careMost case reportsRapid cyclingManic conversionSpontaneous maniaAntidepressant medicationReuptake inhibitorsAntidepressant exposureBipolar depressionCase reportManic episodesMood destabilizationSpontaneous episodesDistressing conditionSevere depressionClinical recommendationsManic symptomsNursing careSelective SSRIPatient screening
2004
Age Effects on Antidepressant-Induced Manic Conversion
Martin A, Young C, Leckman JF, Mukonoweshuro C, Rosenheck R, Leslie D. Age Effects on Antidepressant-Induced Manic Conversion. JAMA Pediatrics 2004, 158: 773-780. PMID: 15289250, DOI: 10.1001/archpedi.158.8.773.Peer-Reviewed Original ResearchConceptsManic conversionAntidepressant classesPatient ageTime-dependent Cox proportional hazards modelsSelective serotonin reuptake inhibitorsCox proportional hazards modelNonbipolar mood disorderSerotonin reuptake inhibitorsProportional hazards modelRisk of conversionAdministrative national databaseEffect of agePharmacy claimsReuptake inhibitorsAntidepressant exposureDrug therapyTricyclic antidepressantsPeripubertal childrenAge effectsBipolar illnessMood disordersHigh riskMental health usersAntidepressant categoryHazards model
1984
On the study of children of parents with affective disorders
Solnit AJ, Leckman JF. On the study of children of parents with affective disorders. American Journal Of Psychiatry 1984, 141: 241-242. PMID: 6691485, DOI: 10.1176/ajp.141.2.241.Peer-Reviewed Original Research
1981
Induction of rapid mood cycling during L-dopa treatment in a bipolar patient
Ko GN, Leckman JF, Heninger GR. Induction of rapid mood cycling during L-dopa treatment in a bipolar patient. American Journal Of Psychiatry 1981, 138: 1624-1625. PMID: 7304798, DOI: 10.1176/ajp.138.12.1624.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansLevodopaMethoxyhydroxyphenylglycolMiddle Aged
1979
Platelet monoamine oxidase (MAO) activity and genetic vulnerability to bipolar (BP) affective illness.
Gershon ES, Targum SD, Leckman JF. Platelet monoamine oxidase (MAO) activity and genetic vulnerability to bipolar (BP) affective illness. Psychopharmacology Bulletin 1979, 15: 27-30. PMID: 419242.Peer-Reviewed Original Research