1998
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
Zheng T, Schlosser S, Dao T, Hingorani R, Crispe I, Boyer J, Flavell R. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13618-13623. PMID: 9811849, PMCID: PMC24868, DOI: 10.1073/pnas.95.23.13618.Peer-Reviewed Original ResearchConceptsCell deathDNA fragmentationFas-induced cell deathCaspase-3-like activityTypical apoptotic featuresCaspase-3NIH 3T3 cellsDFF45/ICADCaspase substratesApoptotic caspasesCaspase-1Apoptotic eventsApoptotic featuresCaspasesMorphological changesAberrant apoptosisNuclear eventsKey substrateNuclear fragmentationHepatocyte cell deathCytoplasmic blebbingApoptosisDifferent morphological changesAltered cleavageFA
1993
Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.
Alvaro D, Cho W, Mennone A, Boyer J. Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. Journal Of Clinical Investigation 1993, 92: 1314-1325. PMID: 8397224, PMCID: PMC288273, DOI: 10.1172/jci116705.Peer-Reviewed Original ResearchConceptsBile duct epithelial cellsDuct epithelial cellsCl-/HCO3Cell depolarizationEpithelial cellsEffect of secretinCl- channel blockerEffects of secretionsCl removalCl- channel activationRat bile duct epithelial cellsKRB mediumMaximal rateRegulation of intracellularBicarbonate secretionNormal rat liverIntracellular pH regulationMM DIDSHCO3- excretionAcid loadBDE cellsSecretinMicrofluorimetric methodRat liverHCO3- influx
1974
Ultrastructural changes in livers of two patients with hypervitaminosis A.
Hruban Z, Russell R, Boyer J, Glagov S, Bagheri S. Ultrastructural changes in livers of two patients with hypervitaminosis A. American Journal Of Pathology 1974, 76: 451-61. PMID: 4416771, PMCID: PMC1910880.Peer-Reviewed Original ResearchConceptsPerisinusoidal fibrosisDistinctive ultrastructural changesChronic hypervitaminosis ALipid-storing cellsUltrastructural changesHypervitaminosis AHypervitaminosis A.Blood flowCellular atrophyFibrosisIto cellsMesenchymal cellsPatientsBasement membraneLiverMassive accumulationCellsNumerous bundlesAtrophyLymphocytesBullaeImpairment