2021
Financial Associations Between Authors of Commentaries on Randomized Clinical Trials of Invasive Cardiovascular Interventions and Trial Sponsors
Hameed I, Mori M, Ahmed A, Naeem N, Oakley CT, Gaudino M, Geirsson A. Financial Associations Between Authors of Commentaries on Randomized Clinical Trials of Invasive Cardiovascular Interventions and Trial Sponsors. JAMA Internal Medicine 2021, 181: 1662-1665. PMID: 34398175, PMCID: PMC8369423, DOI: 10.1001/jamainternmed.2021.4584.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsInvasive cardiovascular interventionsClinical trialsCardiovascular interventionsTrial sponsorsCross-sectional studyTrialsAssociationIntervention
2020
Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions
Gaudino M, Hameed I, Rahouma M, Khan FM, Tam DY, Biondi-Zoccai G, Demetres M, Charlson ME, Ruel M, Crea F, Falk V, Girardi LN, Fremes S, Chikwe J. Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions. JAMA Internal Medicine 2020, 180: 993-1001. PMID: 32478821, PMCID: PMC7265124, DOI: 10.1001/jamainternmed.2020.1670.Peer-Reviewed Original ResearchConceptsPrimary end pointInvasive cardiovascular interventionsPrimary outcomeClinical trialsEnd pointCardiovascular interventionsSignificant differencesComposite primary end pointContemporary Randomized Clinical TrialsStructural interventional cardiologyTrial funding sourceCardiac surgical proceduresRandomized clinical trialsNumber of patientsCross-sectional studyExperimental interventionReporting of trialsTreatment effectsMedian sample sizeLarge treatment effectsContemporary RCTsGuideline recommendationsEvidence-based practiceTrial sponsorshipFavorable outcome