2023
A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery
Robinson N, Rahouma M, Audisio K, Cancelli G, Demetres M, Soletti G, Hameed I, Girardi L, Ruel M, Fremes S, Gaudino M. A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery. Annals Of Thoracic Surgery Short Reports 2023, 1: 537-541. DOI: 10.1016/j.atssr.2023.05.017.Peer-Reviewed Original ResearchCardiothoracic surgeryMost trialsPrimary outcomePrimary end pointComposite primary outcomeMajor clinical eventsMedian fragility indexEligible trialsRandomized trialsTrial armsClinical eventsContemporary trialsFavorable outcomePatient outcomesTrial characteristicsMedian numberSurgeon experienceResults NinetyGeneral surgeryHigh riskSuperiority designSurgerySystematic reviewEnd pointTrials
2020
Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions
Gaudino M, Hameed I, Rahouma M, Khan FM, Tam DY, Biondi-Zoccai G, Demetres M, Charlson ME, Ruel M, Crea F, Falk V, Girardi LN, Fremes S, Chikwe J. Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions. JAMA Internal Medicine 2020, 180: 993-1001. PMID: 32478821, PMCID: PMC7265124, DOI: 10.1001/jamainternmed.2020.1670.Peer-Reviewed Original ResearchConceptsPrimary end pointInvasive cardiovascular interventionsPrimary outcomeClinical trialsEnd pointCardiovascular interventionsSignificant differencesComposite primary end pointContemporary Randomized Clinical TrialsStructural interventional cardiologyTrial funding sourceCardiac surgical proceduresRandomized clinical trialsNumber of patientsCross-sectional studyExperimental interventionReporting of trialsTreatment effectsMedian sample sizeLarge treatment effectsContemporary RCTsGuideline recommendationsEvidence-based practiceTrial sponsorshipFavorable outcome