2021
Characteristics of Randomized Clinical Trials in Surgery From 2008 to 2020
Robinson NB, Fremes S, Hameed I, Rahouma M, Weidenmann V, Demetres M, Morsi M, Soletti G, Di Franco A, Zenati MA, Raja SG, Moher D, Bakaeen F, Chikwe J, Bhatt DL, Kurlansky P, Girardi LN, Gaudino M. Characteristics of Randomized Clinical Trials in Surgery From 2008 to 2020. JAMA Network Open 2021, 4: e2114494. PMID: 34190996, PMCID: PMC8246313, DOI: 10.1001/jamanetworkopen.2021.14494.Peer-Reviewed Original ResearchConceptsMost trialsClinical eventsSurgical interventionSurgical RCTsClinical trialsSurgeon experienceMinor clinical eventsMore surgical interventionsReporting biasMajor clinical eventsRandomized clinical trialsRisk of biasMedian fragility indexMedian sample sizeLarge treatment effectsPrimary outcomeTRIAL REGISTRATIONControl armTrial characteristicsSurgical trialsHigh riskSuperiority designConcerns of biasPrimary analysisRCTs
2019
Disagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach
Gaudino M, Rahouma M, Hameed I, Khan FM, Taggart DP, Flather M, Biondi‐Zoccai G, Fremes SE. Disagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach. Journal Of The American Heart Association 2019, 8: e014638. PMID: 31752642, PMCID: PMC6912987, DOI: 10.1161/jaha.119.014638.Peer-Reviewed Original ResearchConceptsInternal thoracic arteryObservational studyThoracic arterySurvival dataBilateral Internal Thoracic Artery GraftingBilateral internal thoracic artery groupBilateral internal thoracic arteryCox regression hazardPropensity-matched studyLong-term outcomesMost observational studiesArtery GraftingArtery groupImproved survivalControl armImproved outcomesControl groupSurvival curvesArteryBeneficial effectsMeta-analytic approachSurvivalPatientsExperimental groupOutcomes