2024
Tumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization
Tarras E, Sen S, Wang H, Singh I. Tumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization. 2024, a2208-a2208. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2208.Peer-Reviewed Original Research
2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesIntegrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application
Heerdt P, Martin-Flores M, Oakland H, Joseph P, Singh I. Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1929-1937. PMID: 37422337, PMCID: PMC10529383, DOI: 10.1053/j.jvca.2023.06.011.Peer-Reviewed Original ResearchConceptsRight heart catheterizationHeart catheterizationDiastolic functionRV volumesBeat measuresDiagnostic right heart catheterizationReference standardRight ventricular contractilityEnd-diastolic pressurePressure waveform analysisEnd-systolic elastancePotential clinical utilityClinical applicationRV volume measurementsVolume measurementsRV contractilityRV systolicVentricular contractilityRV pressureBland-Altman analysisClinical utilityAnesthetized swineNitric oxideExperimental modelContractilityNoninvasive determinants of pulmonary hypertension in interstitial lung disease
Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.Peer-Reviewed Original ResearchInterstitial lung diseaseFVC/DLCO ratioPH-ILDRight heart catheterizationPulmonary hypertensionHeart catheterizationILD patientsLung diseaseDiagnostic right heart catheterizationRight ventricular systolic pressurePulmonary vascular capacitanceVentricular systolic pressureCharacteristic curve analysisMaximum oxygen uptakeExertional capacityNoninvasive determinantsSystolic pressureVascular capacitancePhysiologic evaluationPatientsNoninvasive variablesMultivariate analysisMmHgDiagnostic standardPotential initiation
2022
Pressure‐based estimation of right ventricular ejection fraction
Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.Peer-Reviewed Original ResearchConceptsRight ventricular ejection fractionCardiac magnetic resonance imagingRight heart catheterizationPulmonary arterial hypertensionMagnetic resonance imagingRV pressure waveformsVentricular ejection fractionRV responseEjection fractionMale PAH patientsCardiac MRI measurementsReceiver operator characteristic curvePressure waveformROC curve analysisClinical reference standardOperator characteristic curveSignificant reductionMeasurements of RVEFPAH patientsArterial hypertensionHeart catheterizationSecondary outcomesStudy cohortLimits of agreementBland-Altman analysis
2021
Impact of right ventricular work and pulmonary arterial compliance on peak exercise oxygen uptake in idiopathic pulmonary arterial hypertension
Messina CMS, Ferreira EVM, Singh I, Fonseca AXC, Ramos RP, Nery LE, Systrom DM, Oliveira RKF, Ota-Arakaki JS. Impact of right ventricular work and pulmonary arterial compliance on peak exercise oxygen uptake in idiopathic pulmonary arterial hypertension. International Journal Of Cardiology 2021, 331: 230-235. PMID: 33545265, DOI: 10.1016/j.ijcard.2021.01.027.Peer-Reviewed Original ResearchConceptsRV stroke work indexPulmonary arterial hypertensionRight heart catheterizationExercise right heart catheterizationIdiopathic pulmonary arterial hypertensionIdiopathic PAHCardiac outputPA complianceArterial hypertensionRight ventricularDynes/s/Mean pulmonary arterial pressurePeak exercise oxygen uptakePeak stroke volume indexPA wedge pressurePeak cardiac indexPulmonary vascular resistanceStroke volume indexStroke work indexCardiopulmonary exercise testingPulmonary arterial pressurePulmonary arterial complianceRight ventricular workAge-adjusted multivariate modelExercise oxygen uptake
2020
Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction
Oakland HT, Joseph P, Elassal A, Cullinan M, Heerdt PM, Singh I. Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary Circulation 2020, 10: 1-10. PMID: 33282205, PMCID: PMC7691918, DOI: 10.1177/2045894020972273.Peer-Reviewed Original ResearchIsolated post-capillary pulmonary hypertensionPost-capillary pulmonary hypertensionCardiopulmonary exercise testRight heart catheterizationPulmonary vascular capacitanceVE/VCOPulmonary hypertensionEnd-tidal carbon dioxideEjection fractionHeart failureExercise testHeart catheterizationVascular capacitanceCombined preElevated left-sided filling pressuresLeft-sided filling pressuresGender-matched control subjectsOxygen uptake efficiency slopeCarbon dioxide slopeCardiopulmonary exercise testingPulmonary artery complianceEnd-tidal COAdjunct diagnostic toolMaximum oxygen uptakeGreater ventilatoryA 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath
Walia A, Singh I, Ryu C, Lutchmansingh DD. A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath. CHEST Journal 2020, 158: e37-e40. PMID: 32654737, PMCID: PMC8097629, DOI: 10.1016/j.chest.2020.02.041.Peer-Reviewed Original ResearchConceptsInterstitial lung diseasePulmonary arterial pressurePulmonary arterial hypertensionArterial hypertensionMycophenolate mofetilLimited sclerodermaArterial pressureCalculated pulmonary vascular resistanceMean pulmonary arterial pressureSevere pulmonary arterial hypertensionStable interstitial lung diseasePulmonary arterial wedge pressureLow-dose prednisonePulmonary vascular resistanceRight heart catheterizationRight atrial pressureLower extremity edemaRight ventricular pressureChronic shortnessCardiac indexChest painHeart catheterizationSick contactsVascular resistanceWedge pressure