2017
Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence
Olsen S, Jin L, Fields RC, Yan Y, Nalbantoglu I. Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence. Human Pathology 2017, 68: 26-33. PMID: 28428104, DOI: 10.1016/j.humpath.2017.03.021.Peer-Reviewed Original ResearchConceptsIntestinal-type gastric adenocarcinomaHigher T stageIntestinal-type cancerGastric adenocarcinomaT stageNodal metastasisN stageLymph node statusSubset of patientsPrimary surgical excisionAmount of tumorCancer-related deathLikelihood of recurrenceDiffuse cancersBetter prognosisHistologic typePrognostic featuresSurgical excisionTumor buddingTumor characteristicsNode statusIntestinal tumorsClinical managementColorectal adenocarcinomaTumor grade
2013
Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice
Dharmarajan S, Newberry EP, Montenegro G, Nalbantoglu I, Davis VR, Clanahan MJ, Blanc V, Xie Y, Luo J, Fleshman JW, Kennedy S, Davidson NO. Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice. Cancer Prevention Research 2013, 6: 1026-1037. PMID: 23921281, PMCID: PMC3791217, DOI: 10.1158/1940-6207.capr-13-0120.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAnimalsCell ProliferationDietary FatsDinoprostoneFatty Acid-Binding ProteinsFatty AcidsFemaleGene DeletionGene Expression Regulation, NeoplasticGenotypeImmunohistochemistryIntestinal MucosaLipidsMiceMice, TransgenicPolymerase Chain ReactionRNA, MessengerSignal TransductionTime FactorsConceptsFatty acid traffickingDietary fat intakeFatty acid speciesFatty acid-binding proteinAcid-binding proteinFatty acid metabolismFat intakeIntestinal fatty acid metabolismIntestinal tumorigenesisCellular proliferationAcid metabolismFatty acid elongationNuclear hormone receptorsΒ-catenin translocationNuclear β-catenin translocationDiet-induced obesityHigh-grade dysplasiaLiver fatty acid-binding proteinIntestinal fatty acid-binding proteinIntestinal tumor formationImportant genetic modifiersSignificant reductionAcid speciesMetabolic compartmentalizationGenetic modifiers