2024
Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials
Pulaski H, Mehta S, Manigat L, Kaufman S, Hou H, Nalbantoglu I, Zhang X, Curl E, Taliano R, Kim T, Torbenson M, Glickman J, Resnick M, Patel N, Taylor C, Bedossa P, Montalto M, Beck A, Wack K. Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials. The Journal Of Pathology Clinical Research 2024, 10: e12395. PMID: 39294925, PMCID: PMC11410674, DOI: 10.1002/2056-4538.12395.Peer-Reviewed Original ResearchConceptsClinical trialsAssessment of disease activityOverall percent agreementLiver biopsyDisease activityPathological assessmentWashout periodHistological assessmentEndpoint assessmentGold standardPercent agreementScoring systemExpert pathologistsSteatohepatitisAverage agreementDigital scoresPathologistsTrials
2009
Tumor Regression following DNA Vaccination and Regulatory T Cell Depletion in neu Transgenic Mice Leads to an Increased Risk for Autoimmunity
Jacob JB, Kong YC, Nalbantoglu I, Snower DP, Wei WZ. Tumor Regression following DNA Vaccination and Regulatory T Cell Depletion in neu Transgenic Mice Leads to an Increased Risk for Autoimmunity. The Journal Of Immunology 2009, 182: 5873-5881. PMID: 19380836, PMCID: PMC3833444, DOI: 10.4049/jimmunol.0804074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCancer VaccinesCell Line, TumorFemaleGenetic Predisposition to DiseaseLymphocyte DepletionMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMice, TransgenicNIH 3T3 CellsRatsReceptor, ErbB-2Remission InductionThyroglobulinThyroiditis, AutoimmuneT-Lymphocytes, RegulatoryVaccines, DNAConceptsRegulatory T-cell depletionT-cell depletionDNA vaccinationTumor regressionTreg depletionCell depletionBALB/c miceAnti-tumor immunityNeu transgenic miceAutoimmune manifestationsImmunotherapeutic regimensAutoimmune thyroiditisTolerant miceMouse thyroglobulinTumor immunityCD25 mAbComplete regressionImmune reactivityAutoimmune diseasesC miceCancer immunotherapyCancer patientsClinical trialsFemale miceLong-term protection