GRAM: A GeneRAlized Model to predict the molecular effect of a non-coding variant in a cell-type specific manner
Lou S, Cotter KA, Li T, Liang J, Mohsen H, Liu J, Zhang J, Cohen S, Xu J, Yu H, Rubin MA, Gerstein M. GRAM: A GeneRAlized Model to predict the molecular effect of a non-coding variant in a cell-type specific manner. PLOS Genetics 2019, 15: e1007860. PMID: 31469829, PMCID: PMC6742416, DOI: 10.1371/journal.pgen.1007860.Peer-Reviewed Original ResearchConceptsNon-coding variantsTranscription factorsLarge linkage disequilibrium blocksCell type-specific mannerPhenotype of interestMolecular effectsFine-mapping causal variantsCell-specific mannerParticular cell typeLinkage disequilibrium blockEvolutionary conservationTF bindingChIP-seqRegulatory networksPerformance of GRAMCausal variantsReporter geneGene expressionExpression profilesGenomic variantsAssociated geneLuciferase assayCell typesK562 cell lineSpecific manner