2024
Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Hu J, Wang S, Zhang H. Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine. ICSA Book Series In Statistics 2024, 423-451. DOI: 10.1007/978-3-031-50690-1_17.Peer-Reviewed Original ResearchAssociation studiesGenetic association studiesPrecision medicineTests of associationHeterogeneous drug responsesDisease risk predictionVariant identificationSignal variantsControl of type I errorDisease riskDrug responseGenomic profilingType I errorRisk predictionGenetic biomarkersVariantsPharmaceutical interventionsMarginal testsAssociation methodAssociationMedicineInterventionIdentificationReplicationDiseaseThe effect of improved metabolic syndrome parameters on live birth
Spitzer T, Diamond M, Wild R, Legro R, Zhang H, Sun F, Ling S, Santoro N. The effect of improved metabolic syndrome parameters on live birth. Fertility And Sterility 2024, 122: 373-375. PMID: 38641159, DOI: 10.1016/j.fertnstert.2024.04.020.Peer-Reviewed Original ResearchMetabolic syndrome Z-scoreLifestyle interventionLive birthsLive birth rateMetabolic syndrome parametersZ-scoreMetabolic syndromeUnexplained infertilityIntrauterine inseminationOvarian stimulationSyndrome parametersMetabolic parametersObese WomenBirth outcomesLive birth outcomesIntervention phaseImprove metabolic syndromeSecondary analysisFisher's exact testStudy participantsZ-score differenceLifestyle modificationStudent's t-testBirth rateLogistic regressionTENSOR QUANTILE REGRESSION WITH LOW-RANK TENSOR TRAIN ESTIMATION.
Liu Z, Lee C, Zhang H. TENSOR QUANTILE REGRESSION WITH LOW-RANK TENSOR TRAIN ESTIMATION. The Annals Of Applied Statistics 2024, 18: 1294-1318. PMID: 38682044, PMCID: PMC11046526, DOI: 10.1214/23-aoas1835.Peer-Reviewed Original ResearchTensor trainCoefficient tensorRate of convergenceLow-rankQuantile regression frameworkApproximation-based methodVariation penaltyHuman intelligenceQuantile regression modelEstimation algorithmMRI image dataAsymptotic normalityArray of imagesScalar outcomeEmpirical performanceImage dataTrained estimatorDimensionalityNumerical studyMagnetic resonance imaging imagesQuantile regressionTensorRegression frameworkTT estimationImagesCost-effectiveness analysis of expectant versus active management for treatment of persistent pregnancies of unknown location
WALTER J, BARNHART K, KOELPER N, SANTORO N, ZHANG H, THOMAS T, HUANG H, HARVIE H, Network N. Cost-effectiveness analysis of expectant versus active management for treatment of persistent pregnancies of unknown location. American Journal Of Obstetrics And Gynecology 2024 PMID: 38552817, DOI: 10.1016/j.ajog.2024.03.035.Peer-Reviewed Original ResearchQuality-adjusted life yearsTwo-dose methotrexateUterine evacuationExpectant managementIncremental cost-effectiveness ratioPersistent pregnancyCost-effectiveness ratioSurgical managementCost-effectiveness acceptability curvesPersistent pregnancy of unknown locationLife yearsLower-risk patient populationsSerum human chorionic gonadotropinPregnancies of unknown locationLaparoscopic surgical managementRate of salpingectomyManagement of pregnancyMean quality-adjusted life yearsMulticenter randomized trialRisk patient populationLower mean costsCosts of surgical interventionsHuman chorionic gonadotropinLower quality-adjusted life yearsAcceptability curvesHeterogeneity Analysis on Multi-State Brain Functional Connectivity and Adolescent Neurocognition
Wang S, Constable T, Zhang H, Zhao Y. Heterogeneity Analysis on Multi-State Brain Functional Connectivity and Adolescent Neurocognition. Journal Of The American Statistical Association 2024, 119: 851-863. DOI: 10.1080/01621459.2024.2311363.Peer-Reviewed Original ResearchHow to minimize the dropout and crossover in an infertility trial?
Huang H, Kuang H, Thomas T, Wei D, Zhang H. How to minimize the dropout and crossover in an infertility trial? Fertility And Sterility 2024, 121: 905-908. PMID: 38316206, DOI: 10.1016/j.fertnstert.2024.01.035.Peer-Reviewed Original ResearchTowards precision oncology discovery: four less known genes and their unknown interactions as highest-performed biomarkers for colorectal cancer
Liu Y, Xu Y, Li X, Chen M, Wang X, Zhang N, Zhang H, Zhang Z. Towards precision oncology discovery: four less known genes and their unknown interactions as highest-performed biomarkers for colorectal cancer. Npj Precision Oncology 2024, 8: 13. PMID: 38243058, PMCID: PMC10799029, DOI: 10.1038/s41698-024-00512-1.Peer-Reviewed Original ResearchFibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
Al-Hendy A, Segars J, Taylor H, González F, Siblini H, Zamah M, Alkelani H, Singh B, Flores V, Christman G, Johnson J, Huang H, Zhang H. Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids. BMJ Open 2024, 14: e078989. PMID: 38216200, PMCID: PMC10806662, DOI: 10.1136/bmjopen-2023-078989.Peer-Reviewed Original ResearchConceptsUnexplained infertilityIntrauterine inseminationInstitutional review boardCumulative live birth rateUterine fibroidsLive birth rateCause of infertilityFood and Drug AdminstrationGonadotropin hormone-releasing hormoneGreen tea extractDouble-blind clinical trialNon-surgical treatment optionsTimed intrauterine inseminationUterine fibroid sizeOvarian stimulationQuality of Life Questionnaire scoresHormone-releasing hormoneLocal institutional review boardInfertility treatmentNational Institute of Child HealthInstitute of Child HealthMiscarriage rateBirth rateReproductive-age womenEndometrial qualityOptimal and Safe Estimation for High-Dimensional Semi-Supervised Learning
Deng S, Ning Y, Zhao J, Zhang H. Optimal and Safe Estimation for High-Dimensional Semi-Supervised Learning. Journal Of The American Statistical Association 2024, ahead-of-print: 1-12. DOI: 10.1080/01621459.2023.2277409.Peer-Reviewed Original ResearchSemi-supervised estimatorConditional mean functionMean functionSupervised estimationParameters of linear modelsSemi-supervised learningRegression parametersEstimation problemLinear modelSupplementary materialsTheoretical resultsParameter estimationSemi-supervised settingUnlabeled dataLabeled dataEstimationMinimaxMisspecificationNumerical simulationsDataFunctionLearningProblemData analysisUse of random integration to test equality of high dimensional covariance matrices.
Jiang Y, Wen C, Jiang Y, Wang X, Zhang H. Use of random integration to test equality of high dimensional covariance matrices. Statistica Sinica 2024, 33: 2359-2380. PMID: 37799490, PMCID: PMC10550010, DOI: 10.5705/ss.202020.0486.Peer-Reviewed Original Research
2023
Nonparametric Statistical Inference via Metric Distribution Function in Metric Spaces
Wang X, Zhu J, Pan W, Zhu J, Zhang H. Nonparametric Statistical Inference via Metric Distribution Function in Metric Spaces. Journal Of The American Statistical Association 2023, ahead-of-print: 1-13. DOI: 10.1080/01621459.2023.2277417.Peer-Reviewed Original ResearchMetric spaceStatistical inferenceGlivenko-CantelliCorrespondence theoremEuclidean spaceGlivenko-Cantelli theoremDistribution functionNonparametric statistical inferenceDonsker propertyProbability measuresGeneral spaceRandom objectsTheoremMeasurement theorySupplementary materialsEuclideanSpaceIndependence testInferenceDonskerCorrespondenceNonparametricHypercubeMetricsFunctionIdentification and validation of supervariants reveal novel loci associated with human white matter microstructure
Wang S, Li T, Zhao B, Dai W, Yao Y, Li C, Li T, Zhu H, Zhang H. Identification and validation of supervariants reveal novel loci associated with human white matter microstructure. Genome Research 2023, 34: gr.277905.123. PMID: 38190638, PMCID: PMC10904010, DOI: 10.1101/gr.277905.123.Peer-Reviewed Original ResearchASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES
Hosseinzadeh P, Schone E, Peck J, Craig L, Zhang H, Legro R, Diamond M, Santoro N, Hansen K. ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES. Fertility And Sterility 2023, 120: e170-e171. DOI: 10.1016/j.fertnstert.2023.08.507.Peer-Reviewed Original ResearchModerate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity
Vitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.Peer-Reviewed Original ResearchLive birth rateSteps/dayPhysical activityInfertility trialsLifestyle modificationUnexplained infertilityObese womenBirth rateClomiphene citrate treatmentUS fertility centersClinical pregnancy rateLifestyle modification programTime of enrollmentModerate physical activityPhysical activity goalsMiscarriage rateFertility centerIntrauterine inseminationFitbit activity trackerPregnancy rateSecondary analysisCitrate treatmentActivity goalsModification programWomenPrednisone vs Placebo and Live Birth in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization
Sun Y, Cui L, Lu Y, Tan J, Dong X, Ni T, Yan J, Guan Y, Hao G, Liu J, Zhang B, Wei D, Hong Y, He Y, Qi J, Xu B, Lu J, Zhang Q, Zhao S, Ji X, Du X, Zhang J, Liu J, Wang J, Huang Y, Huang D, Du Y, Vankelecom H, Zhang H, Chen Z. Prednisone vs Placebo and Live Birth in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization. JAMA 2023, 329: 1460-1468. PMID: 37129654, PMCID: PMC10155063, DOI: 10.1001/jama.2023.5302.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureFrozen-thawed embryo transferBiochemical pregnancy lossLive birthsImplant failurePlacebo groupPrednisone groupPreterm deliveryEmbryo transferPregnancy lossRisk of preterm deliveryRates of biochemical pregnancyEmbryo transfer cyclesGood-quality embryosLive birth rateLive birth outcomesTreatment of recurrent implantation failureStatistically significant between-group differencesHistory of 2Randomized clinical trialsProbability of implantationImmune-regulatory agentSignificant between-group differencesNeonatal complicationsWeeks gestationStatistical Methodologies for Analyzing Genomic Data
Duan F, Zhang H. Statistical Methodologies for Analyzing Genomic Data. Springer Handbooks 2023, 621-634. DOI: 10.1007/978-1-4471-7503-2_32.Peer-Reviewed Original ResearchLinear discriminant analysisEmpirical Bayesian approachDifferent clustering methodsModel-based clusteringNeural networkStatistical methodologyK-meansVector machineMicroarray data analysisColon cancer datasetBayesian approachClassification methodRand indexStatistical issuesClustering methodMultiple comparison issuesMicroarray dataCancer datasetsComparison issuesHierarchical clusteringT-statisticAlgorithmClassificationClusteringGenomic dataPros and cons of Mendelian randomization
Zhang H. Pros and cons of Mendelian randomization. Fertility And Sterility 2023, 119: 913-916. PMID: 36990264, PMCID: PMC10234673, DOI: 10.1016/j.fertnstert.2023.03.029.Peer-Reviewed Original ResearchDeep learning identified genetic variants for COVID‐19‐related mortality among 28,097 affected cases in UK Biobank
Liu Z, Dai W, Wang S, Yao Y, Zhang H. Deep learning identified genetic variants for COVID‐19‐related mortality among 28,097 affected cases in UK Biobank. Genetic Epidemiology 2023, 47: 215-230. PMID: 36691909, PMCID: PMC10006374, DOI: 10.1002/gepi.22515.Peer-Reviewed Original ResearchAssessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor H, Singh B, Flaminia A, Flores V, Christman G, Huang H, Johnson J, Zhang H. Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. Nutrients 2023, 15: 320. PMID: 36678191, PMCID: PMC9861948, DOI: 10.3390/nu15020320.Peer-Reviewed Original ResearchConceptsReproductive-aged womenLiver function testsUterine fibroidsUnexplained infertilityClomiphene citrateSerum liver function testsEpigallocatechin gallateSigns of drugSerum folate levelsGreen tea catechinsHepatic safetyPremenopausal womenProspective cohortDaily doseLiver injuryFunction testsTreatment armsLiver toxicityClinical studiesCommon causeFolate levelsEarly safety assessmentInterim analysisNormal rangeUse of EGCGAnti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause
Santoro N, Flyckt R, Davis A, Finkelstein J, Crawford S, Sun F, Derby C, Morrison A, Sluss P, Zhang H. Anti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause. Obstetrics And Gynecology 2023, 141: 331-340. PMID: 36649324, PMCID: PMC9858351, DOI: 10.1097/aog.0000000000005049.Peer-Reviewed Original ResearchConceptsFinal menstrual periodAnti-Müllerian hormone levelsAMH levelsNatural menopauseHormone levelsUndetectable AMH levelsCommunity-based studyOvarian conservationOvarian reserveAMH measurementOvarian failureMenstrual periodSurgery dateHysterectomyLinear mixed modelingMenopauseSurvival analysisPatientsImmediate reductionMixed modelingWomenOvariesSimilar patternRapid declineBSO