1986
Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs.
Baylen B, Ogata H, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs. Circulation 1986, 73: 1042-1049. PMID: 3754496, DOI: 10.1161/01.cir.73.5.1042.Peer-Reviewed Original ResearchConceptsFull-term lambsLeft ventricular performanceVolume infusionPreterm lambsVentricular performanceStroke workLeft ventricular peak dP/dtLeft ventricleVentricular peak dP/dtLeft ventricular end-diastolic volumeFull-term newborn lambsVentricular end-diastolic volumeLeft ventricular stroke workPeak dP/dtGreater stroke workPostnatal circulatory adaptationSystemic vascular resistanceVentricular stroke workFull-term animalsDays gestational ageEnd-diastolic volumeLeft ventricular pressureDP/dtVascular resistancePulmonary function
1983
Permeability of premature lamb lungs to protein and the effect of surfactant on that permeability
Jobe A, Ikegami M, Jacobs H, Jones S, Conaway D. Permeability of premature lamb lungs to protein and the effect of surfactant on that permeability. Journal Of Applied Physiology 1983, 55: 169-176. PMID: 6554276, DOI: 10.1152/jappl.1983.55.1.169.Peer-Reviewed Original ResearchCardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs
Jobe A, Jacobs H, Ikegami M, Jones S. Cardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs. Pediatric Research 1983, 17: 444-448. PMID: 6553821, DOI: 10.1203/00006450-198306000-00002.Peer-Reviewed Original ResearchConceptsSurfactant instillationPremature lambsOnly ventilator settingPulmonary artery pressureDays gestational ageSurfactant treatmentArtery pressureCesarean sectionRespiratory supportCardiovascular effectsLung functionGestational ageCardiovascular statusInspiratory pressureRespiratory statusTransient deteriorationCardiac outputAortic pressureTracheal instillationVentilator settingsInfant ventilatorRegional bloodHeart rateInstillationBody weightLeft ventricular performance and regional blood flows before and after ductus arteriosus occlusion in premature lambs treated with surfactant.
Baylen B, Ogata H, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. Left ventricular performance and regional blood flows before and after ductus arteriosus occlusion in premature lambs treated with surfactant. Circulation 1983, 67: 837-843. PMID: 6687448, DOI: 10.1161/01.cir.67.4.837.Peer-Reviewed Original ResearchConceptsPatent ductus arteriosusSystemic blood flowBlood flowVentricular performanceLV end-diastolic pressureEarly pathologic manifestationsOvert LV dysfunctionRight PDA shuntEnd-diastolic pressureHours of lifeLeft ventricular performanceRadionuclide-labeled microspheresDuctus arteriosus occlusionRegional blood flowPDA shuntLV dysfunctionPremature lambsRight shuntDuctus arteriosusEjection fractionPreterm lambsHemodynamic consequencesCardiac outputLeft ventriculographyPathologic manifestations