1984
Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant.
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant. Journal Of Clinical Investigation 1984, 73: 848-856. PMID: 6546766, PMCID: PMC425089, DOI: 10.1172/jci111280.Peer-Reviewed Original ResearchConceptsPieces of lungBlood flow distributionPulmonary blood flow distributionLungs of lambsMechanical ventilationRight ductal shuntPulmonary blood flowConstant distending pressurePeriod of ventilationGroups of lambsDuctal shuntPremature lambsAtelectatic areasSurfactant instillationVentricular outputTracheal instillationDistending pressureBlood flowLungLung piecesVentilationInstillationBirthLambsNatural surfactant
1983
Cardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs
Jobe A, Jacobs H, Ikegami M, Jones S. Cardiovascular Effects of Surfactant Suspensions Given by Tracheal Instillation to Premature Lambs. Pediatric Research 1983, 17: 444-448. PMID: 6553821, DOI: 10.1203/00006450-198306000-00002.Peer-Reviewed Original ResearchConceptsSurfactant instillationPremature lambsOnly ventilator settingPulmonary artery pressureDays gestational ageSurfactant treatmentArtery pressureCesarean sectionRespiratory supportCardiovascular effectsLung functionGestational ageCardiovascular statusInspiratory pressureRespiratory statusTransient deteriorationCardiac outputAortic pressureTracheal instillationVentilator settingsInfant ventilatorRegional bloodHeart rateInstillationBody weight
1982
Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates
Jacobs H, Jobe A, Ikegami M, Glatz T, Jones S, Barajas L. Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates. Pediatric Research 1982, 16: 424-429. PMID: 6920645, DOI: 10.1203/00006450-198206000-00005.Peer-Reviewed Original ResearchConceptsRespiratory failureDistal airwaysRespiratory distress syndromeMin of ageDays gestational agePressure-volume curvesClinical deteriorationClinical responsePremature lambsDistress syndromePosttreatment groupGestational ageMechanical ventilationProgressive dilatationUntreated lungsPremature babiesTracheal instillationBlood gasAlveolar washSurfactant replacementBody weightLung structureAirwayMinimum surface tensionHistologic measurements