2003
Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex
Bogue CW, Zhang PX, McGrath J, Jacobs HC, Fuleihan RL. Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 556-561. PMID: 12522149, PMCID: PMC141034, DOI: 10.1073/pnas.0236979100.Peer-Reviewed Original ResearchConceptsB cell developmentB cellsChimeric miceT cell-dependent antigensT cell-independent antigensSerum IgM levelsCell developmentMature B cellsIgM levelsImpaired B cell developmentAntibody responseIgG antibodiesPlasma cellsBone marrowAbsence of HexLymphocyte developmentMiceTargeted disruptionHomozygous disruptionAntigenCellsHomeobox gene HexMarrowDramatic increaseAntibodies
2000
Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter
Denson L, Karpen S, Bogue C, Jacobs H. Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter. AJP Gastrointestinal And Liver Physiology 2000, 279: g347-g355. PMID: 10915644, DOI: 10.1152/ajpgi.2000.279.2.g347.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCarrier ProteinsCOS CellsGene Expression RegulationGenetic Complementation TestHepatoblastomaHomeodomain ProteinsHumansLiverLiver NeoplasmsMembrane Transport ProteinsMolecular Sequence DataMutagenesisOligonucleotide ProbesOrganic Anion Transporters, Sodium-DependentPromoter Regions, GeneticRatsRecombinant Fusion ProteinsSymportersTranscription FactorsTranscription, GeneticTumor Cells, CulturedConceptsHomeobox gene HexDivergent homeobox gene HexNtcp promoterHex proteinHep G2 cellsElectrophoretic mobility shift assaysMobility shift assaysHeterologous promoter constructsDominant-negative formG2 cellsSpecific nuclear proteinLuciferase reporter constructsNuclear proteinsGene promoterShift assaysCOS cellsBasal luciferase activityReporter constructsPromoter regionBile acid cotransporterPromoter constructsResponse elementNegative formPromoterAcid cotransporter