1990
Effect of artificial surfactant on pulmonary function in preterm and full-term lambs
Gladstone I, Ray A, Salafia C, Perez-Fontan J, Mercurio M, Jacobs H. Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. Journal Of Applied Physiology 1990, 69: 465-472. PMID: 2121700, DOI: 10.1152/jappl.1990.69.2.465.Peer-Reviewed Original ResearchConceptsFunctional residual capacityFull-term lambsMean lung volumePreterm lambsLung volumeResidual capacityTest agentsFC-100Higher minimum surface tensionsRespiratory failureLung functionPulmonary functionLung expansionAlveolar washMinimum surface tensionDynamic complianceArtificial surfactantQualitative histologyOxygenationLambsAgentsGas exchangePretermComplianceHistology
1989
Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment.
Gladstone I, Ehrenkranz R, Jacobs H. Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment. Pediatrics 1989, 84: 1072-6. PMID: 2587137, DOI: 10.1542/peds.84.6.1072.Peer-Reviewed Original ResearchConceptsPulmonary function testsChronic lung diseaseFunction testsLung diseaseFluid balanceTotal pulmonary resistanceHours of treatmentFirst dosePulmonary resistanceUrine outputGestational ageRespiratory statusBirth weightExpiratory timeDexamethasone treatmentClinical teamDynamic complianceFluid shiftsInfantsDexamethasoneExtubationSignificant differencesTreatmentDiseaseHoursAntenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits
Gladstone I, Mercurio M, Devenny S, Jacobs H. Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits. Journal Of Applied Physiology 1989, 67: 1377-1382. PMID: 2793738, DOI: 10.1152/jappl.1989.67.4.1377.Peer-Reviewed Original ResearchConceptsDynamic compliancePulmonary functionLung resistanceTotal lung conductanceTotal lung resistancePulmonary function testsRespiratory distress syndromeConsistent tidal volumeAntenatal corticosteroidsAntenatal steroidsIntramuscular betamethasonePostnatal surfactantDistress syndromeFunction testsCombination therapyPulmonary mechanicsExpiratory timePremature rabbitsTidal volumeStatic complianceLung conductanceFirst breathDay 27Day 25Steroids
1987
Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits
Fiascone J, Jacobs H, Moya F, Mercurio M, Lima D. Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits. Pediatric Research 1987, 22: 730-735. PMID: 3431959, DOI: 10.1203/00006450-198712000-00024.Peer-Reviewed Original ResearchConceptsAntenatal corticosteroidsIntratracheal surfactantPulmonary complianceDynamic complianceAlveolar surfactant contentHigher dynamic complianceAntenatal exposurePreterm rabbitsPreterm animalsSingle therapyAlveolar lavageTidal volumeCorticosteroidsFirst breathFetusesDay 25Compliance studiesVentilationRabbitsComplianceCompliance measurementsLavageGestationBetamethasoneTherapy