2024
Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic
Faust J, Renton B, Bongiovanni T, Chen A, Sheares K, Du C, Essien U, Fuentes-Afflick E, Haywood T, Khera R, King T, Li S, Lin Z, Lu Y, Marshall A, Ndumele C, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor H, Watson K, Yancy C, Krumholz H. Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2438918. PMID: 39392630, PMCID: PMC11581672, DOI: 10.1001/jamanetworkopen.2024.38918.Peer-Reviewed Original ResearchConceptsCOVID-19 public health emergencyNon-HispanicPublic health emergencyOther Pacific IslanderExcess mortalityAlaska NativesUS populationExcess deathsRates of excess mortalityCross-sectional study analyzed dataYears of potential lifeMortality relative riskNon-Hispanic whitesCross-sectional studyPacific IslandersStudy analyzed dataAll-cause mortalityEthnic groupsMortality disparitiesMortality ratioTotal populationDeath certificatesEthnic disparitiesMain OutcomesDecedent age
2021
Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers
Chen R, Suchard MA, Krumholz HM, Schuemie MJ, Shea S, Duke J, Pratt N, Reich CG, Madigan D, You SC, Ryan PB, Hripcsak G. Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers. Hypertension 2021, 78: 591-603. PMID: 34304580, PMCID: PMC8363588, DOI: 10.1161/hypertensionaha.120.16667.Peer-Reviewed Original Research
2019
Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis
Suchard MA, Schuemie MJ, Krumholz HM, You SC, Chen R, Pratt N, Reich CG, Duke J, Madigan D, Hripcsak G, Ryan PB. Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis. The Lancet 2019, 394: 1816-1826. PMID: 31668726, PMCID: PMC6924620, DOI: 10.1016/s0140-6736(19)32317-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCalcium Channel BlockersChildCohort StudiesComparative Effectiveness ResearchDatabases, FactualDiureticsEvidence-Based MedicineFemaleHeart FailureHumansHypertensionMaleMiddle AgedMyocardial InfarctionStrokeYoung AdultConceptsNon-dihydropyridine calcium channel blockersCalcium channel blockersThiazide-like diureticsChannel blockersEnzyme inhibitorsDrug classesHazard ratioCurrent guidelinesFirst-line antihypertensive drug classesComparative effectivenessFirst-line drug classesNew-user cohort designDihydropyridine calcium channel blockerElectronic health record databaseFirst-line classesAngiotensin receptor blockersAntihypertensive drug classesAcute myocardial infarctionHealth record databaseReal-world evidenceMedical Research CouncilMillions of patientsAustralian National HealthOptimal monotherapyReceptor blockers
2018
Physical activity and mental health – Author's reply
Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Physical activity and mental health – Author's reply. The Lancet Psychiatry 2018, 5: 874. PMID: 30245184, DOI: 10.1016/s2215-0366(18)30354-7.Peer-Reviewed Original Research
2015
Balloon animals, guitars, and fewer blood draws: applying strategies from pediatrics to the treatment of hospitalized adults.
O'Brien MR, Rosenthal MS, Dharmarajan K, Krumholz HM. Balloon animals, guitars, and fewer blood draws: applying strategies from pediatrics to the treatment of hospitalized adults. Annals Of Internal Medicine 2015, 162: 726-7. PMID: 25984849, DOI: 10.7326/m14-2219.Peer-Reviewed Original Research
2013
Parental Immigration Status is Associated with Children’s Health Care Utilization: Findings from the 2003 New Immigrant Survey of US Legal Permanent Residents
Yun K, Fuentes-Afflick E, Curry LA, Krumholz HM, Desai MM. Parental Immigration Status is Associated with Children’s Health Care Utilization: Findings from the 2003 New Immigrant Survey of US Legal Permanent Residents. Maternal And Child Health Journal 2013, 17: 1913-1921. PMID: 23329165, PMCID: PMC4089976, DOI: 10.1007/s10995-012-1217-2.Peer-Reviewed Original ResearchConceptsHealth care utilizationCare utilizationParental immigration statusAnnual examChild healthChild health care utilizationChild health statusDental careGroup of childrenDental servicesExcellent healthMedical attentionHealth statusLogistic regressionImmigration statusChildrenPermanent residentsHealthNational sampleStatusImmigrant adultsExamParent immigration statusSocioeconomic characteristicsTemporary residents
2011
Use of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study
Dorfman AL, Fazel R, Einstein AJ, Applegate KE, Krumholz HM, Wang Y, Christodoulou E, Chen J, Sanchez R, Nallamothu BK. Use of Medical Imaging Procedures With Ionizing Radiation in Children: A Population-Based Study. JAMA Pediatrics 2011, 165: 458-464. PMID: 21199972, PMCID: PMC3686496, DOI: 10.1001/archpediatrics.2010.270.Peer-Reviewed Original ResearchConceptsDiagnostic imaging proceduresTomographic scanImaging proceduresRetrospective cohort analysisPopulation-based ratesPediatric populationPlain radiographyCohort analysisHigh dosesMedical diagnostic imaging proceduresStudy periodAppropriate useChildrenHigh rateMedical imaging proceduresScansFrequent useHealth care marketUS health care marketYearsPatientsInfantsPopulationCare marketUnitedHealthcare
2010
Patterns of moderate and vigorous physical activity in obese and overweight compared with non‐overweight children
DORSEY KB, HERRIN J, KRUMHOLZ HM. Patterns of moderate and vigorous physical activity in obese and overweight compared with non‐overweight children. Pediatric Obesity 2010, 6: e547-e555. PMID: 20883127, PMCID: PMC3815589, DOI: 10.3109/17477166.2010.490586.Peer-Reviewed Original ResearchConceptsVigorous physical activityOW/OBNon-overweight childrenMVPA boutsPhysical activityGreater body mass index z-scoreVPA boutsOW/OB groupBody mass index z-scoreMean daily MVPANon-overweight groupLess physical activityIndex z-scoreMinutes of MVPANon-overweight peersObese childrenObese participantsOverweight childrenOB groupDaily MVPASustained MVPADistinct patternsOB participantsMVPAConsecutive boutsDo Self- or Parent-Reported Dietary, Physical Activity, and Sedentary Behaviors Predict Worsening Obesity in Children?
Dorsey KB, Mauldon M, Magraw R, Yu S, Krumholz HM. Do Self- or Parent-Reported Dietary, Physical Activity, and Sedentary Behaviors Predict Worsening Obesity in Children? The Journal Of Pediatrics 2010, 157: 566-571. PMID: 20542293, PMCID: PMC2936814, DOI: 10.1016/j.jpeds.2010.04.062.Peer-Reviewed Original ResearchConceptsBMI z-scoreRisk factorsZ-scoreFamily historySedentary behaviorPhysical activityRisk behaviorsRoutine healthcare visitsPhysical activity behaviorHealthcare visitsObese patientsDiabetes mellitusObese childrenAcanthosis nigricansMedical recordsPediatric cliniciansBMI valuesObesityRandom effects regression analysisGreater riskActivity behaviorOverweightPatientsRegression analysisVisitsApplying Practice Recommendations for the Prevention and Treatment of Obesity in Children and Adolescents
Dorsey KB, Mauldon M, Magraw R, Valka J, Yu S, Krumholz HM. Applying Practice Recommendations for the Prevention and Treatment of Obesity in Children and Adolescents. Clinical Pediatrics 2010, 49: 137-145. PMID: 20080520, DOI: 10.1177/0009922809346567.Peer-Reviewed Original ResearchConceptsCross-sectional analysisObese patientsFifth visitDocumentation of BMIFirst clinic visitTreatment of obesityLongitudinal analysisIndividual risk behaviorsClinic visitsClinician adherenceMedical recordsWeight managementObesity preventionFirst visitClinicians' attentionRisk behaviorsPatientsPractice recommendationsVisitsOverweightBMIPreventionAdherenceTreatmentObesity
2009
The Utility of Shorter Epochs in Direct Motion Monitoring
Dorsey K, Herrin J, Krumholz H, Irwin M. The Utility of Shorter Epochs in Direct Motion Monitoring. Research Quarterly For Exercise And Sport 2009, 80: 460-468. PMID: 19791632, PMCID: PMC3152374, DOI: 10.1080/02701367.2009.10599584.Peer-Reviewed Original Research
2008
An algorithm for identifying physical activity patterns from motion data.
Dorsey KB, Herrin J, Krumholz HM. An algorithm for identifying physical activity patterns from motion data. Pediatric Exercise Science 2008, 20: 305-18. PMID: 18714120, DOI: 10.1123/pes.20.3.305.Peer-Reviewed Original ResearchACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities
Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO, Smith SC, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Faxon DP, Halperin JL, Hiratzka LF, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities. Circulation 2008, 117: e350-e408. PMID: 18483207, DOI: 10.1161/circualtionaha.108.189742.Peer-Reviewed Original ResearchACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons
Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO, Smith SC, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Faxon DP, Halperin JL, Hiratzka LF, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Journal Of The American College Of Cardiology 2008, 51: e1-e62. PMID: 18498951, DOI: 10.1016/j.jacc.2008.02.032.Peer-Reviewed Original Research
2005
Validity of Using an Electronic Medical Record for Assessing Quality of Care in an Outpatient Setting
Benin AL, Vitkauskas G, Thornquist E, Shapiro ED, Concato J, Aslan M, Krumholz HM. Validity of Using an Electronic Medical Record for Assessing Quality of Care in an Outpatient Setting. Medical Care 2005, 43: 691-698. PMID: 15970784, DOI: 10.1097/01.mlr.0000167185.26058.8e.Peer-Reviewed Original ResearchConceptsElectronic medical recordsManagement of pharyngitisMedical recordsHealth Plan Employer DataDiagnostic testsEpisode of pharyngitisOutpatient electronic medical recordsProportion of episodesDiagnosis of pharyngitisOutpatient settingTotal episodesPharyngitisEmployer DataElectronic databasesDiagnostic testingClinical encountersMeasures of qualityEpisodesComplete evaluationCareAssessing QualityPediatricsYearsProportionDiagnosisDiagnosis, Evaluation, and Treatment of Childhood Obesity in Pediatric Practice
Dorsey KB, Wells C, Krumholz HM, Concato J. Diagnosis, Evaluation, and Treatment of Childhood Obesity in Pediatric Practice. JAMA Pediatrics 2005, 159: 632-638. PMID: 15996996, DOI: 10.1001/archpedi.159.7.632.Peer-Reviewed Original ResearchConceptsBody mass indexRisk of overweightHospital-based clinicsHealth maintenance visitsRate of diagnosisType of treatmentComorbid diseasesMass indexOverweight childrenChildhood obesityMedical recordsTreatment recommendationsHigh burdenPediatric practiceRoutine screeningOverweightClinical practiceMaintenance visitsDiagnosisEncounter notesFormal diagnosisTreatmentChildrenSingle-parent householdsRiskDiscovering the Full Spectrum of Cardiovascular Disease
Benjamin EJ, Jessup M, Flack JM, Krumholz HM, Liu K, Nadkarni VM, Rhoades DA, Rodriguez BL, Scott RP, Taylor MP, Velazquez EJ, Winkleby MA. Discovering the Full Spectrum of Cardiovascular Disease. Circulation 2005, 111: e124-33. PMID: 15769754, DOI: 10.1161/01.cir.0000157742.95689.65.Peer-Reviewed Original ResearchAdolescentAdultAge FactorsAgedArteriosclerosisAsianBlack or African AmericanBody Mass IndexCardiovascular DiseasesChildCohort StudiesComorbidityFemaleGlucose IntoleranceHawaiiHealth SurveysHumansIncidenceIndians, North AmericanJapanMaleMexican AmericansMiddle AgedMinority GroupsRisk FactorsSex FactorsUnited StatesWhite People
2003
Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record
BENIN AL, VITKAUSKAS G, THORNQUIST E, SHIFFMAN RN, CONCATO J, KRUMHOLZ HM, SHAPIRO ED. Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record. The Pediatric Infectious Disease Journal 2003, 22: 1043-1047. PMID: 14688562, DOI: 10.1097/01.inf.0000100577.76542.af.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsChildChild, PreschoolDiagnostic Tests, RoutineDrug Resistance, MultipleDrug UtilizationElectronic Data ProcessingFemaleHumansLogistic ModelsMalePharyngitisProbabilityRegistriesRetrospective StudiesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexStatistics, NonparametricConceptsElectronic medical recordsOveruse of antibioticsDiagnostic testingMedical recordsEpisode of pharyngitisPediatric outpatient settingProportion of episodesOutpatient settingAntibiotic useScarlet feverPharyngitisChildren 3Diagnostic testsPatientsAntibioticsAppropriate useCliniciansWeeksEpisodesOveruseUseful rolePrescribingFeverClinicTesting