2020
Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015
Zhong Q, Gao Y, Zheng X, Chen J, Masoudi FA, Lu Y, Feng Y, Hu S, Zhang Q, Huang C, Wang Y, Krumholz HM, Li X, Zhou Y. Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015. JAMA Network Open 2020, 3: e2021182. PMID: 33095248, PMCID: PMC7584924, DOI: 10.1001/jamanetworkopen.2020.21182.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionProcess of careHospital mortalityMyocardial infarctionOdds ratioAngiotensin receptor blockersCross-sectional studyOutcomes of careReceptor blockersReperfusion therapyPatient characteristicsTherapy useCare measuresPatient hospitalizationIdeal patientOutcome measuresMAIN OUTCOMEΒ-blockersAMI managementPatientsEnzyme inhibitorsSignificant geographic variationMortalityCareHospitalization
2019
Traditional Chinese Medicine Use in the Treatment of Acute Heart Failure in Western Medicine Hospitals in China: Analysis From the China PEACE Retrospective Heart Failure Study
Yu Y, Spatz ES, Tan Q, Liu S, Lu Y, Masoudi FA, Schulz WL, Krumholz HM, Li J, Group T. Traditional Chinese Medicine Use in the Treatment of Acute Heart Failure in Western Medicine Hospitals in China: Analysis From the China PEACE Retrospective Heart Failure Study. Journal Of The American Heart Association 2019, 8: e012776. PMID: 31364457, PMCID: PMC6761625, DOI: 10.1161/jaha.119.012776.Peer-Reviewed Original ResearchConceptsTraditional Chinese medicineAcute heart failureHeart failureEvidence-based therapiesWestern Medicine HospitalTCM useMedicine HospitalEvidence-based therapy useTraditional Chinese medicine useChinese medicine useCoronary artery diseaseHeart Failure StudyHierarchical logistic regression modelsLogistic regression modelsSalvia miltiorrhizaRandom sampleHospital bleedingPatient's bleedingPatient characteristicsArtery diseaseTherapy useMedicine useHospital characteristicsRetrospective analysisHospital use
2016
Fibrinolytic therapy in hospitals without percutaneous coronary intervention capabilities in China from 2001 to 2011: China PEACE-retrospective AMI study
Li J, Li X, Ross JS, Wang Q, Wang Y, Desai NR, Xu X, Nuti SV, Masoudi FA, Spertus JA, Krumholz HM, Jiang L, Group F. Fibrinolytic therapy in hospitals without percutaneous coronary intervention capabilities in China from 2001 to 2011: China PEACE-retrospective AMI study. European Heart Journal Acute Cardiovascular Care 2016, 6: 232-243. PMID: 26787648, DOI: 10.1177/2048872615626656.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionFibrinolytic therapyMyocardial infarctionPercutaneous coronary intervention capabilitySequential cross-sectional studiesChina PEACE-Retrospective AMI StudyPrimary reperfusion strategyPercutaneous coronary interventionLittle clinical evidenceCross-sectional studyQuality of careTwo-stage random samplingCoronary interventionHospital delayNeedle timeReperfusion strategySymptom onsetTherapy useClinical evidenceEmergency departmentMedian admissionIdeal patientPatientsWeighted proportion
2015
National assessment of statin therapy for patients with acute myocardial infarction, 2001–11: insight from the China PEACE-Retrospective Acute Myocardial Infarction study
Zhang L, Li J, Li X, Nasir K, Zhang H, Wu Y, Hu S, Wang Q, Downing N, Desai N, Masoudi F, Spertus J, Krumholz H, Jiang L, Group O. National assessment of statin therapy for patients with acute myocardial infarction, 2001–11: insight from the China PEACE-Retrospective Acute Myocardial Infarction study. The Lancet 2015, 386: s42. DOI: 10.1016/s0140-6736(15)00623-6.Peer-Reviewed Original ResearchIntensive statin therapyAcute myocardial infarctionAcute Myocardial Infarction StudyStatin therapyMyocardial Infarction StudyMyocardial infarctionStatin useCardiovascular diseaseLow-density lipoprotein cholesterolStatin therapy useLong-term mortalityUse of statinsNumber of patientsTwo-stage random sampling designMultilevel logistic regression modelsCochran-Armitage testLogistic regression modelsWestern rural regionStatin regimensEligible patientsHospital mortalityLipoprotein cholesterolFamily Planning CommissionIntensive therapyTherapy use
2005
Racial Differences in Reperfusion Therapy Use in Patients Hospitalized With Myocardial Infarction: A Regional Phenomenon
Rathore S, Frederick P, Every N, Barron H, Krumholz H. Racial Differences in Reperfusion Therapy Use in Patients Hospitalized With Myocardial Infarction: A Regional Phenomenon. ACC Current Journal Review 2005, 14: 2-3. DOI: 10.1016/j.accreview.2005.09.013.Peer-Reviewed Original ResearchTherapy useThe Impact of Clinical Trials on the Use of Hormone Replacement Therapy
Kim N, Gross C, Curtis J, Stettin G, Wogen S, Choe N, Krumholz HM. The Impact of Clinical Trials on the Use of Hormone Replacement Therapy. Journal Of General Internal Medicine 2005, 20: 1026-1031. PMID: 16307628, PMCID: PMC1490267, DOI: 10.1111/j.1525-1497.2005.0221.x.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedClinical Trials as TopicFemaleHormone Replacement TherapyHumansInformation DisseminationInsurance, Pharmaceutical ServicesLongitudinal StudiesMiddle AgedPatient Acceptance of Health CarePractice Patterns, Physicians'Retrospective StudiesTreatment RefusalUnited StatesConceptsWomen's Health InitiativeHormone replacement therapyHRT useHRT discontinuationReplacement therapyHealth initiativesHormone replacement therapy useLocal practice patternsHRT prescriptionHRT usersMarked regional variationPrescription fillingTherapy useClinical behaviorClinical trialsPractice patternsSubstantial geographic variationTrial publicationsDiscontinuationHealth databasesTrial dataAge groupsRapid effectsWest South CentralTrial resultsRacial differences in reperfusion therapy use in patients hospitalized with myocardial infarction: A regional phenomenon
Rathore SS, Frederick PD, Every NR, Barron HV, Krumholz HM. Racial differences in reperfusion therapy use in patients hospitalized with myocardial infarction: A regional phenomenon. American Heart Journal 2005, 149: 1074-1081. PMID: 15976791, PMCID: PMC2790272, DOI: 10.1016/j.ahj.2004.08.018.Peer-Reviewed Original ResearchConceptsTherapy useMyocardial infarctionBlack patientsReperfusion therapyWhite patientsRacial differencesLower crude ratesMyocardial Infarction 2Reperfusion therapy ratesCohort of patientsTherapy ratesMultivariable adjustmentClinical contraindicationsNational registryPractice patternsCrude ratePatientsInfarctionGeographic regionsTherapyLower ratesTreatmentNational patternsContraindicationsDifferences
2003
Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage
Krumholz HM, Chen J, Rathore SS, Wang Y, Radford MJ. Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage. American Heart Journal 2003, 146: 242-249. PMID: 12891191, DOI: 10.1016/s0002-8703(03)00237-0.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinCoronary Artery BypassFemaleFibrinolytic AgentsHospitalizationHumansLogistic ModelsMaleMyocardial InfarctionNew EnglandOutcome Assessment, Health CarePractice Patterns, Physicians'Quality of Health CareThrombolytic TherapyUnited StatesConceptsPractice patternsMortality rateReperfusion therapyBetter short-term outcomesMedical therapy useShort-term outcomesQuality of careHierarchical logistic regression modelsMyocardial infarction treatmentLogistic regression modelsTherapy useMyocardial infarctionHospital characteristicsPhysician characteristicsProvider characteristicsBetter outcomesInfarction treatmentPatientsMI treatmentRegional variationLow useRegional differencesAspirinHospitalTherapyRacial differences in acute reperfusion therapy use in patients hospitalized with acute myocardial infarction: A regional phenomenon
Rathore S, Frederick P, Every N, Barron H, Krumholz H. Racial differences in acute reperfusion therapy use in patients hospitalized with acute myocardial infarction: A regional phenomenon. Journal Of The American College Of Cardiology 2003, 41: 518. DOI: 10.1016/s0735-1097(03)82794-8.Peer-Reviewed Original Research
1997
Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction
Krumholz HM, Murillo JE, Chen J, Vaccarino V, Radford MJ, Ellerbeck EF, Wang Y. Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction. JAMA 1997, 277: 1683-1688. PMID: 9169894, DOI: 10.1001/jama.1997.03540450039032.Peer-Reviewed Original ResearchConceptsST-segment elevationAcute myocardial infarctionThrombolytic therapyBundle branch blockMyocardial infarctionChest painElderly patientsMental statusBranch blockTotal ST-segment elevationEligible elderly patientsThrombolytic therapy useRetrospective cohort studyHours of symptomsOnset of symptomsPopulation-based sampleLack of treatmentDirect angioplastyEligible patientsAbsolute contraindicationBypass surgeryCohort studyMedical chartsTherapy useContiguous leads