2005
Adoption of Spironolactone Therapy for Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction in the United States, 1998–2001
Masoudi FA, Gross CP, Wang Y, Rathore SS, Havranek EP, Foody JM, Krumholz HM. Adoption of Spironolactone Therapy for Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction in the United States, 1998–2001. Circulation 2005, 112: 39-47. PMID: 15983243, DOI: 10.1161/circulationaha.104.527549.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesCreatinineDiureticsDrug PrescriptionsFemaleFollow-Up StudiesHeart FailureHumansMaleMineralocorticoid Receptor AntagonistsPatient SelectionPotassiumRandomized Controlled Trials as TopicRisk AssessmentSpironolactoneUnited StatesVentricular Dysfunction, LeftConceptsRandomized Aldactone Evaluation StudyPublication of RALESVentricular systolic dysfunctionHeart failureEnrollment criteriaSpironolactone prescriptionSpironolactone therapySystolic dysfunctionOlder patientsLeft ventricular systolic dysfunctionPatients meeting enrollment criteriaSerial cross-sectional samplesSevere renal dysfunctionSerum creatinine valuesAldactone Evaluation StudyMultivariable logistic regressionSerum potassium valuesSkilled nursing facilitiesNoncardiovascular comorbiditiesSpironolactone useRenal dysfunctionAdverse eventsHospital dischargeAppropriate patientsMultivariable analysis
2003
Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure
Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF, Ordin DL, Krumholz HM. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. American Heart Journal 2003, 146: 250-257. PMID: 12891192, DOI: 10.1016/s0002-8703(03)00189-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCross-Sectional StudiesFemaleHeart FailureHospitalizationHumansMaleMineralocorticoid Receptor AntagonistsPatient SelectionRandomized Controlled Trials as TopicSpironolactoneUnited StatesVentricular Dysfunction, LeftConceptsLeft ventricular systolic functionVentricular systolic functionHeart failureEnrollment criteriaClinical trialsOlder personsSystolic functionRandomized Aldactone Evaluation Study (RALES) trialHospitalized older personsRandomized Intervention TrialTrials of agentsLeft ventricular dysfunctionCongestive heart failureHeart failure patientsAcute care hospitalsCross-sectional studySubgroups of ageCommunity-based practiceTrial eligibilityVentricular dysfunctionFailure patientsOlder patientsCare hospitalMERIT-HFTrial population