2019
Application of the VIRGO taxonomy to differentiate acute myocardial infarction in young women
Sciria CT, Dreyer RP, D'Onofrio G, Safdar B, Krumholz HM, Spatz ES. Application of the VIRGO taxonomy to differentiate acute myocardial infarction in young women. International Journal Of Cardiology 2019, 288: 5-11. PMID: 31031078, DOI: 10.1016/j.ijcard.2019.03.054.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCardiac catheterizationYoung womenNon-obstructive coronary artery diseaseSingle-center retrospective chart reviewYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseRetrospective chart reviewAcute myocardial infarctionProportion of womenUniversal definitionIndex admissionChart reviewArtery diseaseConsecutive womenMyocardial infarctionTreatment strategiesCatheterizationMore young womenType 2Type 1Class IType 4BWomenPatient studies
2016
Practice‐Level Variation in Outpatient Cardiac Care and Association With Outcomes
Clough JD, Rajkumar R, Crim MT, Ott LS, Desai NR, Conway PH, Maresh S, Kahvecioglu DC, Krumholz HM. Practice‐Level Variation in Outpatient Cardiac Care and Association With Outcomes. Journal Of The American Heart Association 2016, 5: e002594. PMID: 26908402, PMCID: PMC4802452, DOI: 10.1161/jaha.115.002594.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmbulatory CareCardiologyFemaleHealth Care CostsHealthcare DisparitiesHeart DiseasesHospitalizationHumansMaleMedicareMiddle AgedOffice VisitsPractice Patterns, Physicians'Process Assessment, Health CareQuality Indicators, Health CareTime FactorsTreatment OutcomeUnited StatesConceptsOutpatient cardiac careCardiac careCardiac servicesPractice-level variationMyocardial perfusion imagingNoncardiac hospitalizationsMedical hospitalizationCardiac catheterizationOffice visitsClinical endpointsOutpatient careLowest quartileOdds ratioCardiology practiceMedicare populationMedicare beneficiariesHospitalizationPerfusion imagingDevice proceduresEfficient carePhysician practicesQuartileCarePractice levelMean payment
2015
Development and Validation of an Algorithm to Identify Planned Readmissions From Claims Data
Horwitz LI, Grady JN, Cohen DB, Lin Z, Volpe M, Ngo CK, Masica AL, Long T, Wang J, Keenan M, Montague J, Suter LG, Ross JS, Drye EE, Krumholz HM, Bernheim SM. Development and Validation of an Algorithm to Identify Planned Readmissions From Claims Data. Journal Of Hospital Medicine 2015, 10: 670-677. PMID: 26149225, PMCID: PMC5459369, DOI: 10.1002/jhm.2416.Peer-Reviewed Original ResearchConceptsSame-hospital readmissionsNegative predictive valuePositive predictive valuePredictive valueReadmission measuresHospital-wide readmission measureGold standard chart reviewAdministrative claims-based algorithmDiagnostic cardiac catheterizationClaims-based algorithmLarge teaching centersAcute care hospitalsSmall community hospitalUnplanned readmissionChart reviewCardiac catheterizationScheduled careSpecificity 96.5Community hospitalReadmissionClaims dataCardiac devicesHealth systemTeaching centerPublic reporting
2012
Building Hospital Management Capacity to Improve Patient Flow for Cardiac Catheterization at a Cardiovascular Hospital in Egypt
Wong R, Hathi S, Linnander EL, Banna A, Maraghi M, Din R, Ahmed A, Hafez AR, Allam AA, Krumholz HM, Bradley EH. Building Hospital Management Capacity to Improve Patient Flow for Cardiac Catheterization at a Cardiovascular Hospital in Egypt. The Joint Commission Journal On Quality And Patient Safety 2012, 38: 147-153. PMID: 22533126, PMCID: PMC3427659, DOI: 10.1016/s1553-7250(12)38019-7.Peer-Reviewed Original ResearchConceptsCardiac catheterizationPre-post intervention studyPercentage of patientsPatient flowPre-intervention periodNational Heart InstituteCatheterization laboratory proceduresResource-limited settingsSubset of proceduresTotal patientsConsecutive patientsMiddle-income countriesCardiovascular HospitalPostintervention periodHeart InstituteHospital careHigh-income countriesQI interventionsPatientsCatheterization proceduresIntervention studiesCatheterizationPatient crowdingWard unitSignificant reduction
2011
Do Imaging Studies Performed in Physician Offices Increase Downstream Utilization? An Empiric Analysis of Cardiac Stress Testing With Imaging
Chen J, Fazel R, Ross JS, McNamara RL, Einstein AJ, Al-Mallah M, Krumholz HM, Nallamothu BK. Do Imaging Studies Performed in Physician Offices Increase Downstream Utilization? An Empiric Analysis of Cardiac Stress Testing With Imaging. JACC Cardiovascular Imaging 2011, 4: 630-637. PMID: 21679898, PMCID: PMC3319749, DOI: 10.1016/j.jcmg.2011.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCardiac CatheterizationChi-Square DistributionEchocardiography, StressEmpirical ResearchFemaleHealthcare DisparitiesHumansInsurance, HealthLogistic ModelsMaleMiddle AgedMyocardial Perfusion ImagingMyocardial RevascularizationOffice VisitsOutpatient Clinics, HospitalPractice Patterns, Physicians'Predictive Value of TestsResidence CharacteristicsTime FactorsUnited StatesYoung AdultConceptsMyocardial perfusion imagingSubsequent myocardial perfusion imagingProportion of patientsStress echocardiographyCardiac catheterizationHospital outpatient settingPhysician's officeOutpatient settingStress testingSubsequent cardiac testingCardiac stress testingDownstream resource utilizationHospital outpatient facilitiesCardiac testingPrivate health insuranceDownstream testingOffice imagingPerfusion imagingCatheterizationImaging studiesOutpatient imagingPatientsHealth insuranceLower ratesHigh rate
2009
Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction
Ko DT, Ross JS, Wang Y, Krumholz HM. Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 3: 54-62. PMID: 20123672, PMCID: PMC3024143, DOI: 10.1161/circoutcomes.109.858456.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiac CatheterizationChi-Square DistributionComorbidityFemaleHemorrhageHospitalizationHumansLikelihood FunctionsLogistic ModelsMaleMedicareMyocardial InfarctionPatient SelectionPractice Patterns, Physicians'Risk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionCardiac catheterization useCardiac catheterizationInappropriate indicationsAMI patientsAppropriate indicationsMyocardial infarctionRisk scoreCardiology/American Heart Association class IBaseline cardiovascular riskOlder Medicare patientsHigh-risk patientsDemographic factorsMore comorbiditiesCardiovascular riskOlder patientsMale sexProcedure indicationFemale sexMedicare patientsAmerican CollegeAMI admissionsMedicare feePatientsCatheterization
2008
Regional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction
Ko DT, Wang Y, Alter DA, Curtis JP, Rathore SS, Stukel TA, Masoudi FA, Ross JS, Foody JM, Krumholz HM. Regional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2008, 51: 716-723. PMID: 18279735, DOI: 10.1016/j.jacc.2007.10.039.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterization useBaseline riskCardiac catheterizationMyocardial infarctionCardiology/American Heart Association classificationRisk-standardized mortality ratesAmerican Heart Association classificationCardiac catheterization ratesGRACE risk scoreHigh-risk patientsClass I patientsClass III patientsClass II patientsPatient appropriatenessCatheterization ratesHospital admissionI patientsPrimary outcomeAMI patientsII patientsIII patientsAppropriate indicationsInvasive strategyPhysician characteristics
2007
Certificate of Need Regulation and Cardiac Catheterization Appropriateness After Acute Myocardial Infarction
Ross JS, Ho V, Wang Y, Cha SS, Epstein AJ, Masoudi FA, Nallamothu BK, Krumholz HM. Certificate of Need Regulation and Cardiac Catheterization Appropriateness After Acute Myocardial Infarction. Circulation 2007, 115: 1012-1019. PMID: 17283258, DOI: 10.1161/circulationaha.106.658377.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionCardiac catheterizationHospital coronary artery bypass graft surgeryCoronary artery bypass graft surgeryArtery bypass graft surgeryLower ratesUS acute care hospitalsCardiac catheterization capabilitiesChart-abstracted dataBypass graft surgeryDay of admissionAcute care hospitalsComplex medical careQuality of careGraft surgeryCatheterization ratesClinical characteristicsCON regulationsHospital characteristicsMedicare patientsRetrospective analysisCatheterizationHealthcare costsFull cohort
2006
Delay in the Diagnosis of Acute Myocardial Infarction: Effect on Quality of Care and Its Assessment
Graff LG, Wang Y, Borkowski B, Tuozzo K, Foody JM, Krumholz HM, Radford MJ. Delay in the Diagnosis of Acute Myocardial Infarction: Effect on Quality of Care and Its Assessment. Academic Emergency Medicine 2006, 13: 931-938. PMID: 16894002, DOI: 10.1197/j.aem.2006.04.016.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge DistributionAgedAged, 80 and overAngina, UnstableAspirinCohort StudiesConnecticutEvidence-Based MedicineFemaleFibrinolytic AgentsHumansMaleMyocardial InfarctionPatient AdmissionQuality Assurance, Health CareQuality of Health CareRetrospective StudiesTime FactorsConceptsAcute myocardial infarctionAdmission diagnosisBeta blockersQuality of careMyocardial infarctionDiagnosis of AMICharacteristics of patientsPercutaneous coronary interventionPrincipal discharge diagnosisEvidence-based therapiesRate of administrationCoronary interventionCardiac catheterizationDischarge diagnosisPrincipal diagnosisFrequency of delaysDischarge statusPatient careAdmissionAMI diagnosisPatientsDiagnosisMedicare casesCareInfarctionGender Differences in Treatment of Heart Failure and Acute Myocardial Infarction
Gold LD, Krumholz HM. Gender Differences in Treatment of Heart Failure and Acute Myocardial Infarction. Cardiology In Review 2006, 14: 180-186. PMID: 16788330, DOI: 10.1097/01.crd.0000194093.53005.f0.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHeart failureMyocardial infarctionCoronary artery bypass graft surgeryNational Heart Failure ProjectArtery bypass graft surgeryLeft ventricular ejection fractionShort-term mortality rateEnzyme inhibitor prescriptionHeart Failure ProjectBypass graft surgeryPercutaneous coronary interventionVentricular ejection fractionCooperative Cardiovascular ProjectRisk of mortalityQuality of carePoor quality careGraft surgeryInhibitor prescriptionCoronary interventionFibrinolytic therapyReadmission ratesCardiac catheterizationEjection fractionACE inhibitors
2004
Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction
Rathore SS, Masoudi FA, Havranek EP, Krumholz HM. Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction. The American Journal Of Medicine 2004, 117: 811-822. PMID: 15589484, PMCID: PMC2790535, DOI: 10.1016/j.amjmed.2004.06.034.Peer-Reviewed Original ResearchConceptsBeta-blocker useMyocardial infarctionWhite patientsCoronary revascularizationBlack patientsRacial differencesCardiac catheterization useLower crude ratesUse of aspirinDay of admissionHealth care useTreatment of patientsAcute myocardial infarctionService Medicare beneficiariesMedical record dataQuality of careElderly feeRevascularization useAspirin useMultivariable adjustmentElderly patientsCardiac catheterizationCardiac proceduresCare useCrude rate
2003
Sex Differences in Use of Coronary Revascularization in Elderly Patients After Acute Myocardial Infarction A Tale of Two Therapies
Rathore SS, Foody JM, Radford MJ, Krumholz HM. Sex Differences in Use of Coronary Revascularization in Elderly Patients After Acute Myocardial Infarction A Tale of Two Therapies. CHEST Journal 2003, 124: 2079-2086. PMID: 14665483, DOI: 10.1378/chest.124.6.2079.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRisk-standardized ratesPercutaneous coronary interventionCoronary revascularizationElderly patientsCardiac catheterizationRevascularization therapyMedicare patientsCoronary artery bypass graft surgeryArtery bypass graft surgerySex differencesMultivariable logistic regression modelCrude overall ratesBypass graft surgeryCoronary revascularization ratesType of therapyMedical record dataLogistic regression modelsRevascularization useCABG surgeryGraft surgeryMultivariable adjustmentRevascularization ratesCoronary interventionHospital admission
2002
Race and sex differences in the refusal of cardiac catheterization among elderly patients hospitalized with acute myocardial infarction
Rathore SS, Ordin DL, Krumholz HM. Race and sex differences in the refusal of cardiac catheterization among elderly patients hospitalized with acute myocardial infarction. American Heart Journal 2002, 144: 1052-1056. PMID: 12486430, DOI: 10.1067/mhj.2002.126122.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterizationPatient raceElderly patientsMyocardial infarctionSex differencesRefusal rateWhite womenCardiac catheterization useCardiac procedure useRisk-standardized ratesWhite menBlack womenBlack menMultivariate adjustmentOverall cohortHospital characteristicsMedical recordsMedicare beneficiariesCatheterizationPatientsProcedure useSex differences in cardiac catheterization after acute myocardial infarction: the role of procedure appropriateness.
Rathore SS, Wang Y, Radford MJ, Ordin DL, Krumholz HM. Sex differences in cardiac catheterization after acute myocardial infarction: the role of procedure appropriateness. Annals Of Internal Medicine 2002, 137: 487-93. PMID: 12230349, DOI: 10.7326/0003-4819-137-6-200209170-00008.Peer-Reviewed Original ResearchConceptsCardiac catheterization useAcute myocardial infarctionCardiac catheterizationMyocardial infarctionMultivariable adjustmentEquivocal indicationsSex differencesProcedure useChart-abstracted dataLower crude ratesRisk-standardized ratesU.S. acute care hospitalsDays of hospitalizationAcute care hospitalsClinical guidelinesHospital characteristicsMedicare patientsCrude rateInappropriate treatmentRetrospective analysisCatheterizationInfarctionPatientsElderly personsWomen
2001
Sex Differences in Cardiac Catheterization: The Role of Physician Gender
Rathore SS, Chen J, Wang Y, Radford MJ, Vaccarino V, Krumholz HM. Sex Differences in Cardiac Catheterization: The Role of Physician Gender. JAMA 2001, 286: 2849-2856. PMID: 11735761, DOI: 10.1001/jama.286.22.2849.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterizationMale physiciansFemale physiciansPatient sexPhysician sexCardiac proceduresRetrospective medical record reviewSex differencesUS acute care hospitalsProcedure useCardiac procedure useDay of admissionMedical record reviewCooperative Cardiovascular ProjectAcute care hospitalsCare hospitalMultivariable analysisRecord reviewPotential confoundersMyocardial infarctionPhysician genderCatheterizationMAIN OUTCOMEClinical careRacial Differences in the Use of Cardiac Catheterization after Acute Myocardial Infarction
Chen J, Rathore S, Radford M, Wang Y, Krumholz H. Racial Differences in the Use of Cardiac Catheterization after Acute Myocardial Infarction. New England Journal Of Medicine 2001, 344: 1443-1449. PMID: 11346810, DOI: 10.1056/nejm200105103441906.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterizationBlack patientsWhite patientsMyocardial infarctionCooperative Cardiovascular ProjectPatterns of careAdjusted mortality rateRacial differencesBlack physiciansStudy cohortCatheterizationInfarctionMedicare beneficiariesMortality ratePatientsPhysiciansWhite physiciansLower ratesSignificant interactionCohortRaceDifferencesCare
2000
Mental Disorders and Use of Cardiovascular Procedures After Myocardial Infarction
Druss BG, Bradford DW, Rosenheck RA, Radford MJ, Krumholz HM. Mental Disorders and Use of Cardiovascular Procedures After Myocardial Infarction. JAMA 2000, 283: 506-511. PMID: 10659877, DOI: 10.1001/jama.283.4.506.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCohort StudiesComorbidityCoronary Artery BypassFemaleHumansLogistic ModelsMaleMental DisordersMultivariate AnalysisMyocardial InfarctionOutcome Assessment, Health CareRetrospective StudiesSocioeconomic FactorsSurvival AnalysisUnited StatesConceptsPercutaneous transluminal coronary angioplastyComorbid mental disordersAcute myocardial infarctionCardiac catheterizationMyocardial infarctionMental disordersProvider factorsCardiovascular proceduresRates of PTCACoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryPatients 65 yearsRetrospective cohort studyTransluminal coronary angioplastyLong-term outcomesCooperative Cardiovascular ProjectCoronary revascularization proceduresSex-based differencesGraft surgeryIndex hospitalizationCohort studyCoronary angioplastyMedical chartsRevascularization procedures
1999
Do “America's Best Hospitals” Perform Better for Acute Myocardial Infarction?
Chen J, Radford M, Wang Y, Marciniak T, Krumholz H. Do “America's Best Hospitals” Perform Better for Acute Myocardial Infarction? New England Journal Of Medicine 1999, 340: 286-292. PMID: 9920954, DOI: 10.1056/nejm199901283400407.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinFemaleHealth Care SurveysHospitalsHumansLogistic ModelsMaleMedicareMultivariate AnalysisMyocardial InfarctionOutcome and Process Assessment, Health CareQuality of Health CareSeverity of Illness IndexThrombolytic TherapyUnited StatesConceptsAcute myocardial infarctionShort-term mortalityMyocardial infarctionAmerica's Best HospitalsBest HospitalsSurvival advantageLower short-term mortalityBeta-blocker therapyRates of therapyHigh rateOutcomes of patientsUse of aspirinCooperative Cardiovascular ProjectElderly Medicare beneficiariesType of hospitalQuality of hospitalsReperfusion therapyElderly patientsRate of useBypass surgeryCardiac catheterizationCoronary angioplastyMedicare beneficiariesInfarctionAspirin
1998
Admission to Hospitals With On-Site Cardiac Catheterization Facilities
Krumholz H, Chen J, Murillo J, Cohen D, Radford M. Admission to Hospitals With On-Site Cardiac Catheterization Facilities. Circulation 1998, 98: 2010-2016. PMID: 9808598, DOI: 10.1161/01.cir.98.19.2010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCardiac Care FacilitiesCardiac CatheterizationCohort StudiesCoronary Artery BypassFemaleHealth Care CostsHospital MortalityHospitalizationHumansLength of StayMaleMedical RecordsPilot ProjectsRetrospective StudiesTime FactorsTreatment OutcomeConceptsSite cardiac catheterization facilitiesCardiac catheterization facilitiesAcute myocardial infarctionCatheterization facilitiesType of hospitalReadmission ratesCardiac proceduresMyocardial infarctionHospital costsMortality rateGood short-term clinical outcomesShort-term clinical outcomesLong-term mortality ratesAdjusted readmission ratesCardiac catheterization ratesBaseline patient characteristicsLong-term mortalityRetrospective cohort studyLower readmission ratesElderly Medicare patientsSignificant differencesCatheterization ratesRevascularization ratesCardiac catheterizationCohort study
1993
Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up.
Krumholz HM, Forman DE, Kuntz RE, Baim DS, Wei JY. Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up. Annals Of Internal Medicine 1993, 119: 1084-90. PMID: 8239227, DOI: 10.7326/0003-4819-119-11-199312010-00005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationContraindicationsFemaleFollow-Up StudiesHemodynamicsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationProportional Hazards ModelsQuality of LifeRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsAcute myocardial infarctionCoronary revascularizationMyocardial infarctionElderly patientsComplicated acute myocardial infarctionConsecutive patients 80 yearsCoronary artery bypass surgeryTertiary care teaching hospitalCox proportional hazards modelMedical therapy groupPatients 80 yearsRetrospective cohort studyArtery bypass surgerySevere valvular diseaseSignificant coronary diseaseInvasive cardiovascular proceduresProportional hazards modelQuality of lifeAngioplasty groupSurgery groupBypass surgeryCohort studyCardiac catheterizationCoronary diseaseSerious complications