2011
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
Morgan TM, House JA, Cresci S, Jones P, Allayee H, Hazen SL, Patel Y, Patel RS, Eapen DJ, Waddy SP, Quyyumi AA, Kleber ME, März W, Winkelmann BR, Boehm BO, Krumholz HM, Spertus JA. Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Medical Genomics 2011, 12: 127. PMID: 21957892, PMCID: PMC3190329, DOI: 10.1186/1471-2350-12-127.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAminohydrolasesCohort StudiesFemaleFormate-Tetrahydrofolate LigaseGenetic VariationGenome-Wide Association StudyGenotypeHumansKaplan-Meier EstimateMaleMethylenetetrahydrofolate Dehydrogenase (NADP)Middle AgedMultienzyme ComplexesMyocardial InfarctionPolymorphism, Single NucleotideProportional Hazards ModelsRisk FactorsWhite PeopleConceptsAcute coronary syndromeCoronary syndromeCoronary artery disease patientsKaplan-Meier survival analysisACS risk factorsCoronary artery diseaseUniversity-affiliated hospitalMyocardial infarction patientsPremature myocardial infarctionRace-adjusted analysesACS mortalityArtery diseaseCox regressionBorderline significanceDisease patientsInfarction patientsMyocardial infarctionRisk factorsMortality hazardIndependent cohortSurvival analysisDiverse cohortPatientsRelevant covariatesBackgroundGenome-wide association studies
2005
Quality Improvement Efforts and Hospital Performance
Bradley EH, Herrin J, Mattera JA, Holmboe ES, Wang Y, Frederick P, Roumanis SA, Radford MJ, Krumholz HM. Quality Improvement Efforts and Hospital Performance. Medical Care 2005, 43: 282-292. PMID: 15725985, DOI: 10.1097/00005650-200503000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overCross-Sectional StudiesDrug Utilization ReviewFemaleHospitalsHumansLeadershipMaleMedical Staff, HospitalMiddle AgedMyocardial InfarctionOrganizational CultureOutcome Assessment, Health CarePractice Patterns, Physicians'Quality Indicators, Health CareRegistriesTotal Quality ManagementUnited StatesConceptsAcute myocardial infarctionBeta-blocker prescription ratesQuality improvement effortsMyocardial infarctionBeta-blocker useHospital teaching statusCross-sectional studyQuality improvement interventionsPatient-level dataPhysician leadershipQuality of careHospital performanceHospital quality improvement effortsImprovement effortsQuality improvement strategiesPrescription ratesBorderline significanceNational registryAMI volumeUS hospitalsImprovement interventionsHospitalTeaching statusEvidence baseHigh/medium
2004
Hospital Coronary Artery Bypass Graft Surgery Volume and Patient Mortality, 1998–2000
Rathore SS, Epstein AJ, Volpp KG, Krumholz HM. Hospital Coronary Artery Bypass Graft Surgery Volume and Patient Mortality, 1998–2000. Annals Of Surgery 2004, 239: 110-117. PMID: 14685108, PMCID: PMC1356200, DOI: 10.1097/01.sla.0000103066.22732.b8.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAnalysis of VarianceCause of DeathCoronary Artery BypassCoronary DiseaseFemaleHospital MortalityHumansIncidenceMaleMiddle AgedOdds RatioOutcome Assessment, Health CareProbabilityRegistriesRetrospective StudiesRisk AssessmentSampling StudiesSex DistributionTotal Quality ManagementUnited StatesConceptsLow-volume hospitalsMedium-volume hospitalsHigh-volume hospitalsSurgery volumeMortality riskMortality rateNational Inpatient Sample databaseRisk-standardized mortality ratesHospital CABG volumeHospital mortality rateRisk of mortalityLower mortality riskHealth care purchasersHospital mortalityMultivariable adjustmentVolume hospitalsBorderline significanceCABG volumeRetrospective analysisVolume groupMortality differencesPatientsHospitalLeapfrog GroupReliable marker