Featured Publications
Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans
Jabba S, Erythropel H, Anastas P, Zimmerman J, Jordt S. Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans. JAMA 2023, 330: 1689-1691. PMID: 37812408, PMCID: PMC10562986, DOI: 10.1001/jama.2023.17134.Peer-Reviewed Original ResearchGreen chemistry as just chemistry
Lane M, Rudel H, Wilson J, Erythropel H, Backhaus A, Gilcher E, Ishii M, Jean C, Lin F, Muellers T, Wang T, Torres G, Taylor D, Anastas P, Zimmerman J. Green chemistry as just chemistry. Nature Sustainability 2023, 6: 502-512. DOI: 10.1038/s41893-022-01050-z.Peer-Reviewed Original ResearchFormation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids
Erythropel HC, Jabba SV, DeWinter TM, Mendizabal M, Anastas PT, Jordt SE, Zimmerman JB. Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. Nicotine & Tobacco Research 2018, 21: 1248-1258. PMID: 30335174, PMCID: PMC6698951, DOI: 10.1093/ntr/nty192.Peer-Reviewed Original ResearchConceptsFlavor aldehydesSolvent componentsNuclear magnetic resonance spectroscopyNovel chemical speciesReaction productsPhysiological aqueous solutionE-cigarette liquidsReactive chemical systemsToxicological propertiesCommercial e-liquidsMagnetic resonance spectroscopyE-liquidsAqueous mediaPropylene glycolAqueous solutionPotential toxicological effectsNew compoundsUltraviolet spectroscopyChemical speciesChemical reactionsGas chromatographyChemical systemsResonance spectroscopyToxicological effectsAldehydesDesigning for a green chemistry future
Zimmerman JB, Anastas PT, Erythropel HC, Leitner W. Designing for a green chemistry future. Science 2020, 367: 397-400. PMID: 31974246, DOI: 10.1126/science.aay3060.Peer-Reviewed Original Research
2024
Synthetic cooling agents and nicotine analogs in new tobacco products: tobacco industry strategies to bypass regulation
Jordt S, Erythropel H, Silinski P, Zimmerman J, Anastas P, Jabba S. Synthetic cooling agents and nicotine analogs in new tobacco products: tobacco industry strategies to bypass regulation. 2024, pa4038. DOI: 10.1183/13993003.congress-2024.pa4038.Peer-Reviewed Original ResearchVariability in Constituents of E-Cigarette Products Containing Nicotine Analogues
Erythropel H, Jabba S, Silinski P, Anastas P, Krishnan-Sarin S, Zimmerman J, Jordt S. Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues. JAMA 2024, 332: 753-755. PMID: 39110443, PMCID: PMC11307159, DOI: 10.1001/jama.2024.12408.Peer-Reviewed Original ResearchToxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal
Kassem N, Strongin R, Stroup A, Brinkman M, El-Hellani A, Erythropel H, Etemadi A, Goniewicz M, Hansen E, Kassem N, Li D, Liles S, Noël A, Rezk-Hanna M, Wang Q, Rahman I. Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal. Toxicological Sciences 2024, 201: 159-173. PMID: 39037923, PMCID: PMC11424890, DOI: 10.1093/toxsci/kfae095.Peer-Reviewed Original ResearchWaterpipe tobaccoWaterpipe tobacco smokingPublic health concernTobacco regulationTobacco alternativesHealth concernSmokingIncreased riskYoung adultsHealth effectsAnimal modelsHealthTobacco flavorTobaccoInhalation toxicityPre-packagedBiomarkers of exposureUnited StatesPotential toxicityToxicityWaterpipeIncreasing appealCigaretteAdultsUseA Review of the Toxicity of Ingredients in e-Cigarettes, Including Those Ingredients Having the FDA’s “Generally Recognized as Safe (GRAS)” Regulatory Status for Use in Food
Kassem N, Strongin R, Stroup A, Brinkman M, El-Hellani A, Erythropel H, Etemadi A, Exil V, Goniewicz M, Kassem N, Klupinski T, Liles S, Muthumalage T, Noël A, Peyton D, Wang Q, Rahman I, Valerio L. A Review of the Toxicity of Ingredients in e-Cigarettes, Including Those Ingredients Having the FDA’s “Generally Recognized as Safe (GRAS)” Regulatory Status for Use in Food. Nicotine & Tobacco Research 2024, 26: 1445-1454. PMID: 38783714, PMCID: PMC11494494, DOI: 10.1093/ntr/ntae123.Peer-Reviewed Original ResearchExtract Manufacturers AssociationE-cigarettesE-cigarette productsFood ingredientsFood additivesPrevalence of e-cigarette useGRAS substancesGRASE-liquidsE-cigarette useFoodIngredientsE-cigarette toxicityEvidence of adverse effectsProduct ingredientsToxicity of ingredientsE-liquid ingredientsDrug and Cosmetic ActOral consumptionRegulatory statusElectronic cigarettesChemical compoundsToxicological evaluationProduct labelsRefill liquidsChemical and physiological interactions between e-liquid constituents: cause for concern?
Strongin R, Sharma E, Erythropel H, Kassem N, Noël A, Peyton D, Rahman I. Chemical and physiological interactions between e-liquid constituents: cause for concern? Tobacco Control 2024, tc-2023-058546. PMID: 38658055, DOI: 10.1136/tc-2023-058546.Peer-Reviewed Original ResearchComparison of emissions across tobacco products: A slippery slope in tobacco control
El-Hellani A, Adeniji A, Erythropel H, Wang Q, Lamb T, Mikheev V, Rahman I, Stepanov I, Strongin R, Wagener T, Brinkman M. Comparison of emissions across tobacco products: A slippery slope in tobacco control. Tobacco Induced Diseases 2024, 22: 1-13. PMID: 38560551, PMCID: PMC10980913, DOI: 10.18332/tid/183797.Peer-Reviewed Original ResearchTobacco productsHeated tobacco productsTobacco controlElectronic cigarettesCombustible cigarettesNarrative reviewTobaccoCigaretteNon-target analysisSession lengthData reportingControlled laboratory settingAnalytical method developmentMatrix effectsAssurance measuresActual useLaboratory settingTrap emissionHookahMethod developmentInhaled smokeSmokingReviewAbsolute exposureStatistical analysis
2023
Mechanistic investigation of a Ni-catalyzed electrochemical reductive cleavage of the α-O-4 bond in the lignin model compound benzyl phenyl ether
Lin F, Petrović P, Tse H, Erythropel H, Lam J, Anastas P. Mechanistic investigation of a Ni-catalyzed electrochemical reductive cleavage of the α-O-4 bond in the lignin model compound benzyl phenyl ether. Green Chemistry 2023, 25: 9720-9732. DOI: 10.1039/d3gc01814h.Peer-Reviewed Original ResearchElectrochemical reductive cleavageBenzyl phenyl etherReductive cleavagePhenyl etherO bondReaction mechanismLignin αCarbon paper cathodeO bond scissionCP electrodePaper cathodeRole of methanolElectrode surfaceCatalyst surfaceDFT calculationsProton donorBond scissionRoom temperatureProton transferPhenoxy anionCatalytic cleavageO saltMechanistic routesBenzylic carbonInert atmosphereSynthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’
Jabba S, Erythropel H, Woodrow J, Anastas P, O'Malley S, Krishnan-Sarin S, Zimmerman J, Jordt S. Synthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’. Tobacco Control 2023, tc-2023-058035. PMID: 37380351, PMCID: PMC10753027, DOI: 10.1136/tc-2023-058035.Peer-Reviewed Original ResearchGas chromatography/mass spectrometryChromatography/mass spectrometryWS-3Oral nicotine pouchesSynthetic coolantsMass spectrometryChemical analysisSensory irritancyFlavor additivesAdditivesChemical contentFlavoring agentProductsIrritant activitySpectrometryFlavourantsEffective strategyExtractAgentsNicotine pouchesSynthetic Cooling Agents in California-Marketed "Non-menthol" Cigarette Brands Introduced After the State’s Menthol Ban
Jordt S, Erythropel H, Yang A, O'Malley S, Krishnan-Sarin S, Zimmerman J, Jabba S. Synthetic Cooling Agents in California-Marketed "Non-menthol" Cigarette Brands Introduced After the State’s Menthol Ban. 2023, a2633-a2633. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2633.Peer-Reviewed Original Research
2022
Development of a Ni-promoted, selective electrochemical reductive cleavage of the C–O bond in lignin model compound benzyl phenyl ether
Lin F, TSE H, Erythropel H, Petrović P, Garedew M, Chen J, Lam J, Anastas P. Development of a Ni-promoted, selective electrochemical reductive cleavage of the C–O bond in lignin model compound benzyl phenyl ether. Green Chemistry 2022, 24: 6295-6305. DOI: 10.1039/d2gc01510b.Peer-Reviewed Original ResearchBenzyl phenyl etherO bondBenzylic CPhenyl etherElectrochemical protocolElectrochemical reductive cleavageNoble metal catalystsDivalent metal saltsO bond cleavageSubstrate scope studyMetal catalystsCarbon paperUndivided cellBond cleavageMetal saltsRoom temperatureModel compoundsBenzylic ethersNi foamCatalytic hydrogenolysisAmbient pressureReductive cleavageSelective cleavageNi saltsLignin valorizationEmerging ENDS products and challenges in tobacco control toxicity research
Strongin R, Sharma E, Erythropel H, El-Hellani A, Kassem N, Mikheev V, Noël A, Peyton D, Springer M. Emerging ENDS products and challenges in tobacco control toxicity research. Tobacco Control 2022, 33: 110-115. PMID: 35715171, PMCID: PMC9758272, DOI: 10.1136/tobaccocontrol-2022-057268.Peer-Reviewed Original ResearchSynthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment
Jabba SV, Erythropel HC, Torres DG, Delgado LA, Woodrow JG, Anastas PT, Zimmerman JB, Jordt SE. Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment. Nicotine & Tobacco Research 2022, 24: 1037-1046. PMID: 35167696, PMCID: PMC9199944, DOI: 10.1093/ntr/ntac046.Peer-Reviewed Original ResearchConceptsMargin of exposureE-cigarettesE-liquidsE-cigarette productsWS-23Tobacco product initiationE-cigarette refill liquidsE-cigarette useAdditional health risksHealth risksMenthol-flavoured productsMenthol-flavored e-cigarettesProduct initiationAssociated health risksTobacco productsRefill liquidsSafe marginE-cigarette brandsRiskExposureSynthetic coolantsWS-3Consumer exposureRisk assessment parametersFlavor varietiesWhat to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory
Lane MKM, Garedew M, Deary EC, Coleman CN, Ahrens-Víquez M, Erythropel HC, Zimmerman JB, Anastas PT. What to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory. Chemical Research In Toxicology 2022, 35: 163-198. PMID: 35130693, PMCID: PMC8864617, DOI: 10.1021/acs.chemrestox.1c00380.Peer-Reviewed Original Research
2021
Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users
Jackson A, Green B, Erythropel HC, Kong G, Cavallo DA, Eid T, Gueorguieva R, Buta E, O’Malley S, Krishnan-Sarin S. Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users. Experimental And Clinical Psychopharmacology 2021, 29: 355-365. PMID: 32297782, PMCID: PMC7572568, DOI: 10.1037/pha0000368.Peer-Reviewed Original ResearchCellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes
Jabba S, Diaz A, Caceres A, Erythropel H, Kumar V, Varghese S, Zimmerman J, Jordt S. Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes. 2021, a4296-a4296. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4296.Peer-Reviewed Original Research
2020
Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells
Jabba SV, Diaz AN, Erythropel HC, Zimmerman JB, Jordt SE. Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells. Nicotine & Tobacco Research 2020, 22: s25-s34. PMID: 33320255, PMCID: PMC8224836, DOI: 10.1093/ntr/ntaa185.Peer-Reviewed Original ResearchConceptsRespiratory epithelial cellsBEAS-2B cellsE-cigarette aerosolEpithelial cellsEffect of benzaldehydeE-liquidsMetabolic toxic effectsPrimary human nasal epithelial cellsHuman nasal epithelial cellsInhalation toxicity studiesElectronic nicotine delivery systemsCell metabolic assayNasal epithelial cellsMitochondrial functionAlveolar epithelial cellsE-cigarette liquidsFlavor aldehydesNicotine delivery systemsEnergy metabolic functionsE-cigarette usersEdU cell proliferationConcentration-dependent mannerSpare respiratory capacityInhibits mitochondrial functionLIVE/DEAD cell assay