Featured Publications
Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids
Erythropel HC, Jabba SV, DeWinter TM, Mendizabal M, Anastas PT, Jordt SE, Zimmerman JB. Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. Nicotine & Tobacco Research 2018, 21: 1248-1258. PMID: 30335174, PMCID: PMC6698951, DOI: 10.1093/ntr/nty192.Peer-Reviewed Original ResearchConceptsFlavor aldehydesSolvent componentsNuclear magnetic resonance spectroscopyNovel chemical speciesReaction productsPhysiological aqueous solutionE-cigarette liquidsReactive chemical systemsToxicological propertiesCommercial e-liquidsMagnetic resonance spectroscopyE-liquidsAqueous mediaPropylene glycolAqueous solutionPotential toxicological effectsNew compoundsUltraviolet spectroscopyChemical speciesChemical reactionsGas chromatographyChemical systemsResonance spectroscopyToxicological effectsAldehydesDesigning for a green chemistry future
Zimmerman JB, Anastas PT, Erythropel HC, Leitner W. Designing for a green chemistry future. Science 2020, 367: 397-400. PMID: 31974246, DOI: 10.1126/science.aay3060.Peer-Reviewed Original Research
2022
Emerging ENDS products and challenges in tobacco control toxicity research
Strongin R, Sharma E, Erythropel H, El-Hellani A, Kassem N, Mikheev V, Noël A, Peyton D, Springer M. Emerging ENDS products and challenges in tobacco control toxicity research. Tobacco Control 2022, 33: 110-115. PMID: 35715171, PMCID: PMC9758272, DOI: 10.1136/tobaccocontrol-2022-057268.Peer-Reviewed Original ResearchSynthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment
Jabba SV, Erythropel HC, Torres DG, Delgado LA, Woodrow JG, Anastas PT, Zimmerman JB, Jordt SE. Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment. Nicotine & Tobacco Research 2022, 24: 1037-1046. PMID: 35167696, PMCID: PMC9199944, DOI: 10.1093/ntr/ntac046.Peer-Reviewed Original ResearchConceptsMargin of exposureE-cigarettesE-liquidsE-cigarette productsWS-23Tobacco product initiationE-cigarette refill liquidsE-cigarette useAdditional health risksHealth risksMenthol-flavoured productsMenthol-flavored e-cigarettesProduct initiationAssociated health risksTobacco productsRefill liquidsSafe marginE-cigarette brandsRiskExposureSynthetic coolantsWS-3Consumer exposureRisk assessment parametersFlavor varietiesWhat to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory
Lane MKM, Garedew M, Deary EC, Coleman CN, Ahrens-Víquez M, Erythropel HC, Zimmerman JB, Anastas PT. What to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory. Chemical Research In Toxicology 2022, 35: 163-198. PMID: 35130693, PMCID: PMC8864617, DOI: 10.1021/acs.chemrestox.1c00380.Peer-Reviewed Original Research
2021
Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users
Jackson A, Green B, Erythropel HC, Kong G, Cavallo DA, Eid T, Gueorguieva R, Buta E, O’Malley S, Krishnan-Sarin S. Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users. Experimental And Clinical Psychopharmacology 2021, 29: 355-365. PMID: 32297782, PMCID: PMC7572568, DOI: 10.1037/pha0000368.Peer-Reviewed Original Research
2020
Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells
Jabba SV, Diaz AN, Erythropel HC, Zimmerman JB, Jordt SE. Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells. Nicotine & Tobacco Research 2020, 22: s25-s34. PMID: 33320255, PMCID: PMC8224836, DOI: 10.1093/ntr/ntaa185.Peer-Reviewed Original ResearchConceptsRespiratory epithelial cellsBEAS-2B cellsE-cigarette aerosolEpithelial cellsEffect of benzaldehydeE-liquidsMetabolic toxic effectsPrimary human nasal epithelial cellsHuman nasal epithelial cellsInhalation toxicity studiesElectronic nicotine delivery systemsCell metabolic assayNasal epithelial cellsMitochondrial functionAlveolar epithelial cellsE-cigarette liquidsFlavor aldehydesNicotine delivery systemsEnergy metabolic functionsE-cigarette usersEdU cell proliferationConcentration-dependent mannerSpare respiratory capacityInhibits mitochondrial functionLIVE/DEAD cell assayQuantification of Flavorants and Nicotine in Waterpipe Tobacco and Mainstream Smoke and Comparison to E-cigarette Aerosol
Erythropel HC, Torres D, Woodrow JG, de Winter TM, Falinski MM, Anastas PT, O’Malley S, Krishnan-Sarin S, Zimmerman JB. Quantification of Flavorants and Nicotine in Waterpipe Tobacco and Mainstream Smoke and Comparison to E-cigarette Aerosol. Nicotine & Tobacco Research 2020, 23: 600-604. PMID: 32598451, PMCID: PMC7885788, DOI: 10.1093/ntr/ntaa114.Peer-Reviewed Original ResearchE-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute Lungenschädigung
Schupp JC, Prasse A, Erythropel HC. E-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute Lungenschädigung. Pneumologie 2020, 74: 77-87. PMID: 32016924, PMCID: PMC7366312, DOI: 10.1055/a-1078-8126.Commentaries, Editorials and LettersConceptsSevere acute lung injuryAcute lung injuryTypical disease progressionLung injuryClinical presentationCase definitionDisease progressionE-cigarettesElectronic cigarettesPotential triggersEVALIPatientsInhalation riskPotential inhalation risksReview articleInjuryEpidemiologyCigarettesProgression
2019
Flavorant–Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol
Erythropel HC, Davis LM, de Winter TM, Jordt SE, Anastas PT, O'Malley SS, Krishnan-Sarin S, Zimmerman JB. Flavorant–Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol. American Journal Of Preventive Medicine 2019, 57: 425-427. PMID: 31358341, PMCID: PMC6702051, DOI: 10.1016/j.amepre.2019.04.004.Peer-Reviewed Original Research
2017
The effect of sucralose on flavor sweetness in electronic cigarettes varies between delivery devices
Rosbrook K, Erythropel HC, DeWinter TM, Falinski M, O’Malley S, Krishnan-Sarin S, Anastas PT, Zimmerman JB, Green BG. The effect of sucralose on flavor sweetness in electronic cigarettes varies between delivery devices. PLOS ONE 2017, 12: e0185334. PMID: 28968411, PMCID: PMC5624589, DOI: 10.1371/journal.pone.0185334.Peer-Reviewed Original ResearchConceptsCommercial e-liquidsDelivery systemConcentrations of sucraloseE-liquid aerosolLC/MSE-liquidsVolatile flavor componentsLiquid delivery systemChemical compoundsChemical analysisArtificial sweetenersE-cigarette designFlavor additivesDelivery devicesVolatile constituentsFlavor componentsSweetener sucraloseVolatile chemicalsSweet aromaCartridge systemSufficient concentrationSucraloseEffect of sucralose
2015
Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line
Nardelli TC, Erythropel HC, Robaire B. Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line. PLOS ONE 2015, 10: e0138421. PMID: 26445464, PMCID: PMC4596883, DOI: 10.1371/journal.pone.0138421.Peer-Reviewed Original ResearchConceptsTM4 Sertoli cell lineUpregulated genesSertoli cell lineMajor signal transduction pathwaysCholesterol biosynthesisSignal transduction pathwaysERK/MAPKGene expression studiesCell linesToxicogenomic screeningTransduction pathwaysDNA repairRho signalingDEHP/MEHPExpression studiesGene expressionStress responseGenesToxicogenomic profilesAltered expressionButanediol dibenzoateBiosynthesisMultiple commercial applicationsDioctyl succinateExpression
2014
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure
Erythropel HC, Maric M, Nicell JA, Leask RL, Yargeau V. Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure. Applied Microbiology And Biotechnology 2014, 98: 9967-9981. PMID: 25376446, DOI: 10.1007/s00253-014-6183-8.Peer-Reviewed Original ResearchConceptsDEHP exposureHuman exposureDaily human exposureChronic illnessTolerable daily intake valuesLevels of DEHPBreakdown productsDaily intake valuesUbiquitous environmental contaminantsHospital environmentHigh levelsIntake valuesExposureEndocrine disruptorsHospital equipmentImpact assessment studiesDEHPLatter exposureRiskEnvironmental fateAlternative plasticizersDEHP contaminationBottled waterPatientsLevels