2015
Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line
Nardelli TC, Erythropel HC, Robaire B. Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line. PLOS ONE 2015, 10: e0138421. PMID: 26445464, PMCID: PMC4596883, DOI: 10.1371/journal.pone.0138421.Peer-Reviewed Original ResearchConceptsTM4 Sertoli cell lineUpregulated genesSertoli cell lineMajor signal transduction pathwaysCholesterol biosynthesisSignal transduction pathwaysERK/MAPKGene expression studiesCell linesToxicogenomic screeningTransduction pathwaysDNA repairRho signalingDEHP/MEHPExpression studiesGene expressionStress responseGenesToxicogenomic profilesAltered expressionButanediol dibenzoateBiosynthesisMultiple commercial applicationsDioctyl succinateExpression
2014
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure
Erythropel HC, Maric M, Nicell JA, Leask RL, Yargeau V. Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure. Applied Microbiology And Biotechnology 2014, 98: 9967-9981. PMID: 25376446, DOI: 10.1007/s00253-014-6183-8.Peer-Reviewed Original ResearchMeSH KeywordsDiethylhexyl PhthalateEnvironmental ExposureEnvironmental PollutantsFood ContaminationHumansPlasticizersPlasticsConceptsDEHP exposureHuman exposureDaily human exposureChronic illnessTolerable daily intake valuesLevels of DEHPBreakdown productsDaily intake valuesUbiquitous environmental contaminantsHospital environmentHigh levelsIntake valuesExposureEndocrine disruptorsHospital equipmentImpact assessment studiesDEHPLatter exposureRiskEnvironmental fateAlternative plasticizersDEHP contaminationBottled waterPatientsLevels