Featured Publications
Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans
Jabba S, Erythropel H, Anastas P, Zimmerman J, Jordt S. Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans. JAMA 2023, 330: 1689-1691. PMID: 37812408, PMCID: PMC10562986, DOI: 10.1001/jama.2023.17134.Peer-Reviewed Original ResearchFormation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids
Erythropel HC, Jabba SV, DeWinter TM, Mendizabal M, Anastas PT, Jordt SE, Zimmerman JB. Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. Nicotine & Tobacco Research 2018, 21: 1248-1258. PMID: 30335174, PMCID: PMC6698951, DOI: 10.1093/ntr/nty192.Peer-Reviewed Original ResearchMeSH KeywordsChromatography, GasDose-Response Relationship, DrugElectronic Nicotine Delivery SystemsFlavoring AgentsHEK293 CellsHumansPropylene GlycolTobacco ProductsTRPA1 Cation ChannelTRPV Cation ChannelsVapingConceptsFlavor aldehydesSolvent componentsNuclear magnetic resonance spectroscopyNovel chemical speciesReaction productsPhysiological aqueous solutionE-cigarette liquidsReactive chemical systemsToxicological propertiesCommercial e-liquidsMagnetic resonance spectroscopyE-liquidsAqueous mediaPropylene glycolAqueous solutionPotential toxicological effectsNew compoundsUltraviolet spectroscopyChemical speciesChemical reactionsGas chromatographyChemical systemsResonance spectroscopyToxicological effectsAldehydes
2022
Emerging ENDS products and challenges in tobacco control toxicity research
Strongin R, Sharma E, Erythropel H, El-Hellani A, Kassem N, Mikheev V, Noël A, Peyton D, Springer M. Emerging ENDS products and challenges in tobacco control toxicity research. Tobacco Control 2022, 33: 110-115. PMID: 35715171, PMCID: PMC9758272, DOI: 10.1136/tobaccocontrol-2022-057268.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentElectronic Nicotine Delivery SystemsFlavoring AgentsHumansNicotineTobacco ControlTobacco ProductsSynthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment
Jabba SV, Erythropel HC, Torres DG, Delgado LA, Woodrow JG, Anastas PT, Zimmerman JB, Jordt SE. Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment. Nicotine & Tobacco Research 2022, 24: 1037-1046. PMID: 35167696, PMCID: PMC9199944, DOI: 10.1093/ntr/ntac046.Peer-Reviewed Original ResearchMeSH KeywordsElectronic Nicotine Delivery SystemsFlavoring AgentsHumansMentholRisk AssessmentTobacco ProductsConceptsMargin of exposureE-cigarettesE-liquidsE-cigarette productsWS-23Tobacco product initiationE-cigarette refill liquidsE-cigarette useAdditional health risksHealth risksMenthol-flavoured productsMenthol-flavored e-cigarettesProduct initiationAssociated health risksTobacco productsRefill liquidsSafe marginE-cigarette brandsRiskExposureSynthetic coolantsWS-3Consumer exposureRisk assessment parametersFlavor varieties
2021
Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users
Jackson A, Green B, Erythropel HC, Kong G, Cavallo DA, Eid T, Gueorguieva R, Buta E, O’Malley S, Krishnan-Sarin S. Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users. Experimental And Clinical Psychopharmacology 2021, 29: 355-365. PMID: 32297782, PMCID: PMC7572568, DOI: 10.1037/pha0000368.Peer-Reviewed Original ResearchAdolescentElectronic Nicotine Delivery SystemsFemaleFlavoring AgentsHumansMaleMalusMentholNicotineTobacco Products
2020
Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells
Jabba SV, Diaz AN, Erythropel HC, Zimmerman JB, Jordt SE. Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells. Nicotine & Tobacco Research 2020, 22: s25-s34. PMID: 33320255, PMCID: PMC8224836, DOI: 10.1093/ntr/ntaa185.Peer-Reviewed Original ResearchMeSH KeywordsAerosolsAldehydesElectronic Nicotine Delivery SystemsEpithelial CellsFlavoring AgentsHumansMitochondriaRespiratory SystemConceptsRespiratory epithelial cellsBEAS-2B cellsE-cigarette aerosolEpithelial cellsEffect of benzaldehydeE-liquidsMetabolic toxic effectsPrimary human nasal epithelial cellsHuman nasal epithelial cellsInhalation toxicity studiesElectronic nicotine delivery systemsCell metabolic assayNasal epithelial cellsMitochondrial functionAlveolar epithelial cellsE-cigarette liquidsFlavor aldehydesNicotine delivery systemsEnergy metabolic functionsE-cigarette usersEdU cell proliferationConcentration-dependent mannerSpare respiratory capacityInhibits mitochondrial functionLIVE/DEAD cell assayQuantification of Flavorants and Nicotine in Waterpipe Tobacco and Mainstream Smoke and Comparison to E-cigarette Aerosol
Erythropel HC, Torres D, Woodrow JG, de Winter TM, Falinski MM, Anastas PT, O’Malley S, Krishnan-Sarin S, Zimmerman JB. Quantification of Flavorants and Nicotine in Waterpipe Tobacco and Mainstream Smoke and Comparison to E-cigarette Aerosol. Nicotine & Tobacco Research 2020, 23: 600-604. PMID: 32598451, PMCID: PMC7885788, DOI: 10.1093/ntr/ntaa114.Peer-Reviewed Original ResearchAerosolsElectronic Nicotine Delivery SystemsFlavoring AgentsHumansNicotineTobacco ProductsTobacco UseTobacco, WaterpipeUnited StatesWater Pipe SmokingE-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute Lungenschädigung
Schupp JC, Prasse A, Erythropel HC. E-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute Lungenschädigung. Pneumologie 2020, 74: 77-87. PMID: 32016924, PMCID: PMC7366312, DOI: 10.1055/a-1078-8126.Commentaries, Editorials and LettersMeSH KeywordsAcute Lung InjuryCannabidiolDisease OutbreaksDronabinolElectronic Nicotine Delivery SystemsHumansNicotineRisk FactorsVapingConceptsSevere acute lung injuryAcute lung injuryTypical disease progressionLung injuryClinical presentationCase definitionDisease progressionE-cigarettesElectronic cigarettesPotential triggersEVALIPatientsInhalation riskPotential inhalation risksReview articleInjuryEpidemiologyCigarettesProgression
2019
Flavorant–Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol
Erythropel HC, Davis LM, de Winter TM, Jordt SE, Anastas PT, O'Malley SS, Krishnan-Sarin S, Zimmerman JB. Flavorant–Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol. American Journal Of Preventive Medicine 2019, 57: 425-427. PMID: 31358341, PMCID: PMC6702051, DOI: 10.1016/j.amepre.2019.04.004.Peer-Reviewed Original ResearchAcetalsAerosolsAldehydesElectronic Nicotine Delivery SystemsFlavoring AgentsHumansMentholSolventsUnited StatesUnited States Food and Drug Administration
2017
The effect of sucralose on flavor sweetness in electronic cigarettes varies between delivery devices
Rosbrook K, Erythropel HC, DeWinter TM, Falinski M, O’Malley S, Krishnan-Sarin S, Anastas PT, Zimmerman JB, Green BG. The effect of sucralose on flavor sweetness in electronic cigarettes varies between delivery devices. PLOS ONE 2017, 12: e0185334. PMID: 28968411, PMCID: PMC5624589, DOI: 10.1371/journal.pone.0185334.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultElectronic Nicotine Delivery SystemsFemaleHumansMaleMiddle AgedPsychophysicsSucroseTasteYoung AdultConceptsCommercial e-liquidsDelivery systemConcentrations of sucraloseE-liquid aerosolLC/MSE-liquidsVolatile flavor componentsLiquid delivery systemChemical compoundsChemical analysisArtificial sweetenersE-cigarette designFlavor additivesDelivery devicesVolatile constituentsFlavor componentsSweetener sucraloseVolatile chemicalsSweet aromaCartridge systemSufficient concentrationSucraloseEffect of sucralose