2016
In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity
Boisvert A, Jones S, Issop L, Erythropel HC, Papadopoulos V, Culty M. In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity. Environmental Research 2016, 150: 496-512. PMID: 27423704, DOI: 10.1016/j.envres.2016.06.033.Peer-Reviewed Original ResearchConceptsOrgan cultureDose-response studySensitive developmental windowsFetal Leydig cellsGerm cellsAndrogen productionTesticular functionBiphasic effectSteroid productionReproductive toxicityLeydig cellsSpermatogonial cell lineMonoester metabolitesNeonatal testisSafe alternativeScreening toolDevelopment of compoundsVivo evaluationCell linesMA-10Developmental windowCell line dataCell survivalEndocrine disruptorsPromising compounds
2015
Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line
Nardelli TC, Erythropel HC, Robaire B. Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line. PLOS ONE 2015, 10: e0138421. PMID: 26445464, PMCID: PMC4596883, DOI: 10.1371/journal.pone.0138421.Peer-Reviewed Original ResearchConceptsTM4 Sertoli cell lineUpregulated genesSertoli cell lineMajor signal transduction pathwaysCholesterol biosynthesisSignal transduction pathwaysERK/MAPKGene expression studiesCell linesToxicogenomic screeningTransduction pathwaysDNA repairRho signalingDEHP/MEHPExpression studiesGene expressionStress responseGenesToxicogenomic profilesAltered expressionButanediol dibenzoateBiosynthesisMultiple commercial applicationsDioctyl succinateExpression