2024
A Review of the Toxicity of Ingredients in e-Cigarettes, Including Those Ingredients Having the FDA’s “Generally Recognized as Safe (GRAS)” Regulatory Status for Use in Food
Kassem N, Strongin R, Stroup A, Brinkman M, El-Hellani A, Erythropel H, Etemadi A, Exil V, Goniewicz M, Kassem N, Klupinski T, Liles S, Muthumalage T, Noël A, Peyton D, Wang Q, Rahman I, Valerio L. A Review of the Toxicity of Ingredients in e-Cigarettes, Including Those Ingredients Having the FDA’s “Generally Recognized as Safe (GRAS)” Regulatory Status for Use in Food. Nicotine & Tobacco Research 2024, 26: 1445-1454. PMID: 38783714, PMCID: PMC11494494, DOI: 10.1093/ntr/ntae123.Peer-Reviewed Original ResearchExtract Manufacturers AssociationE-cigarettesE-cigarette productsFood ingredientsFood additivesPrevalence of e-cigarette useGRAS substancesGRASE-liquidsE-cigarette useFoodIngredientsE-cigarette toxicityEvidence of adverse effectsProduct ingredientsToxicity of ingredientsE-liquid ingredientsDrug and Cosmetic ActOral consumptionRegulatory statusElectronic cigarettesChemical compoundsToxicological evaluationProduct labelsRefill liquids
2022
Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment
Jabba SV, Erythropel HC, Torres DG, Delgado LA, Woodrow JG, Anastas PT, Zimmerman JB, Jordt SE. Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment. Nicotine & Tobacco Research 2022, 24: 1037-1046. PMID: 35167696, PMCID: PMC9199944, DOI: 10.1093/ntr/ntac046.Peer-Reviewed Original ResearchConceptsMargin of exposureE-cigarettesE-liquidsE-cigarette productsWS-23Tobacco product initiationE-cigarette refill liquidsE-cigarette useAdditional health risksHealth risksMenthol-flavoured productsMenthol-flavored e-cigarettesProduct initiationAssociated health risksTobacco productsRefill liquidsSafe marginE-cigarette brandsRiskExposureSynthetic coolantsWS-3Consumer exposureRisk assessment parametersFlavor varieties