2024
Chemical and physiological interactions between e-liquid constituents: cause for concern?
Strongin R, Sharma E, Erythropel H, Kassem N, Noël A, Peyton D, Rahman I. Chemical and physiological interactions between e-liquid constituents: cause for concern? Tobacco Control 2024, tc-2023-058546. PMID: 38658055, DOI: 10.1136/tc-2023-058546.Peer-Reviewed Original Research
2020
Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells
Jabba SV, Diaz AN, Erythropel HC, Zimmerman JB, Jordt SE. Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells. Nicotine & Tobacco Research 2020, 22: s25-s34. PMID: 33320255, PMCID: PMC8224836, DOI: 10.1093/ntr/ntaa185.Peer-Reviewed Original ResearchConceptsRespiratory epithelial cellsBEAS-2B cellsE-cigarette aerosolEpithelial cellsEffect of benzaldehydeE-liquidsMetabolic toxic effectsPrimary human nasal epithelial cellsHuman nasal epithelial cellsInhalation toxicity studiesElectronic nicotine delivery systemsCell metabolic assayNasal epithelial cellsMitochondrial functionAlveolar epithelial cellsE-cigarette liquidsFlavor aldehydesNicotine delivery systemsEnergy metabolic functionsE-cigarette usersEdU cell proliferationConcentration-dependent mannerSpare respiratory capacityInhibits mitochondrial functionLIVE/DEAD cell assay