2021
Sex Hormones, Insulin, and Insulin-like Growth Factors in Recurrence of High-Stage Endometrial CancerSex Hormones and Insulin in Endometrial Cancer Recurrence
Merritt MA, Strickler HD, Hutson AD, Einstein MH, Rohan TE, Xue X, Sherman ME, Brinton LA, Yu H, Miller DS, Ramirez NC, Lankes HA, Birrer MJ, Huang GS, Gunter MJ. Sex Hormones, Insulin, and Insulin-like Growth Factors in Recurrence of High-Stage Endometrial CancerSex Hormones and Insulin in Endometrial Cancer Recurrence. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 719-726. PMID: 33622671, PMCID: PMC8026669, DOI: 10.1158/1055-9965.epi-20-1613.Peer-Reviewed Original ResearchConceptsEndometrial cancer recurrenceSex hormonesEndometrial cancerProgesterone receptorCancer recurrenceInsulin/insulin-like growth factor axisRecurrence riskInsulin-like growth factor (IGF) axisInsulin-like growth factorGynecologic Oncology GroupProgression-free survivalEndometrial adenocarcinoma patientsIGF-binding proteinsFuture clinical trialsGrowth factor axisConfidence intervalsIR/IGF1RAdjuvant therapyER positivityIGFBP-3Oncology GroupProspective cohortAdenocarcinoma patientsPretreatment specimensSerum concentrations
2010
Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma
Huang GS, Gunter MJ, Arend RC, Li M, Arias-Pulido H, Prossnitz ER, Goldberg GL, Smith HO. Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma. American Journal Of Obstetrics And Gynecology 2010, 203: 242.e1-242.e5. PMID: 20605134, PMCID: PMC2933955, DOI: 10.1016/j.ajog.2010.04.046.Peer-Reviewed Original ResearchConceptsUterine carcinosarcomaProgesterone receptorDisease progressionEpithelial expressionG protein-coupled receptor 30Early-stage carcinosarcomaAdvanced stage diseaseExpression of GPR30Expression levelsWilcoxon rank sum testRank sum testLower ERalphaReceptor 30PR expressionNormal endometriumEstrogen receptorGPR30Positive cellsCarcinosarcomaLogistic regressionERbetaSum testERalphaAlternative ERsTissue sections
2009
Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma
Huang GS, Arend RC, Li M, Gunter MJ, Chiu LG, Horwitz SB, Goldberg GL. Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. American Journal Of Obstetrics And Gynecology 2009, 200: 457.e1-457.e5. PMID: 19200930, PMCID: PMC2676778, DOI: 10.1016/j.ajog.2008.12.012.Peer-Reviewed Original ResearchConceptsHuman epidermal growth factor receptor 2 (HER2) expressionEpidermal growth factor receptor 2 expressionEstrogen receptor beta expressionGrowth factor receptor expressionEstrogen receptor betaReceptor 2 expressionDisease progressionReceptor expressionEstrogen receptor alphaFactor receptor expressionNormal endometriumUterine carcinosarcomaBeta expressionReceptor alphaReceptor betaHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Insulin-like growth factor receptor expressionAdvanced stage diseaseGrowth factor receptor 2Progesterone receptor expressionInsulin-like growth factor receptorTissue microarray analysisFactor receptor 2Wilcoxon rank sum test