2001
Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice
Zhu G, Flies D, Tamada K, Sun Y, Rodriguez M, Fu Y, Chen L. Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice. The Journal Of Immunology 2001, 167: 2671-2676. PMID: 11509610, DOI: 10.4049/jimmunol.167.5.2671.Peer-Reviewed Original ResearchMeSH Keywords4-1BB LigandAgingAnimalsAntibody FormationAntigen PresentationAntigens, CDBase SequenceB-LymphocytesDNA, ComplementaryHistocompatibility Antigens Class IIIn Vitro TechniquesLigandsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicPhenotypePromoter Regions, GeneticReceptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorSpleenT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 9Tumor Necrosis Factor-alphaConceptsHumoral immune responseTransgenic miceT cellsImmune responseDefective humoral responseAllogeneic T cellsPeripheral B lymphocytesProgressive splenomegalyCTL responsesHumoral responseAg presentationB cellsB lymphocytesSelective depletionMiceCellsLow levelsProgressive depletionResponseSplenomegalySplenocytesLymphocytesIgGUnexpected functionB7-H3: A costimulatory molecule for T cell activation and IFN-γ production
Chapoval A, Ni J, Lau J, Wilcox R, Flies D, Liu D, Dong H, Sica G, Zhu G, Tamada K, Chen L. B7-H3: A costimulatory molecule for T cell activation and IFN-γ production. Nature Immunology 2001, 2: 269-274. PMID: 11224528, DOI: 10.1038/85339.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigens, CDB7 AntigensB7-1 AntigenCells, CulturedCloning, MolecularCytokinesDendritic CellsHumansInterferon-gammaLymphocyte ActivationMolecular Sequence DataProtein IsoformsReceptors, ImmunologicSequence Homology, Amino AcidT-LymphocytesT-Lymphocytes, CytotoxicTranscription, GeneticTumor Cells, CulturedConceptsIFN-γ productionDendritic cellsB7-H3 proteinT cellsPhorbol myristate acetateB7-H3Inducible costimulatorT-lymphocyte antigen-4Cell-mediated immune responsesPeripheral blood mononuclear cellsAllogeneic T cellsBlood mononuclear cellsInterferon-γ ProductionB7 homolog 3Cytotoxic T cellsB7-H3 mRNAB7 family membersActivated T cellsT cell activationT cell receptor signalingPD-1Cell receptor signalingCostimulatory pathwayInflammatory cytokinesAntigen-4
2000
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
Wang S, Zhu G, Chapoval A, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96: 2808-2813. PMID: 11023515, DOI: 10.1182/blood.v96.8.2808.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAmino Acid SequenceAnimalsAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell DivisionCHO CellsCloning, MolecularCricetinaeCricetulusCTLA-4 AntigenDendritic CellsDNA, ComplementaryGenes, ImmunoglobulinHumansImmunoconjugatesImmunoglobulin GInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInterleukin-10Interleukin-2LigandsLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataProtein Structure, TertiaryProteinsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsB7-H2T cellsMonocyte-derived immature dendritic cellsImmature dendritic cellsIL-10 productionSecretion of interleukinT cell proliferationB7-like moleculeT cell moleculesImmunoglobulin fusion proteinDendritic cellsCell surface expressionCD3 ligationSurface expressionChinese hamster ovary cellsCostimulationHamster ovary cellsCellsOvary cellsPutative ligandCTLA4IgInterleukinCD3Fusion proteinICOS
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-1369. PMID: 10581077, DOI: 10.1038/70932.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesB7-H1B7 familyImmune responseT-cell co-stimulatory pathwaysAntigen-specific humoralInterleukin-10 secretionT cell responsesCo-stimulatory moleculesCo-stimulatory pathwaysT cell proliferationAllogeneic antigensInterleukin-10Polyclonal stimuliB7-1Interleukin-2CD28Negative regulationHumoralResponseICOSAntigenSecretion