2001
RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB
Sica G, Zhu G, Tamada K, Liu D, Ni J, Chen L. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB. Blood 2001, 97: 2702-2707. PMID: 11313261, DOI: 10.1182/blood.v97.9.2702.Peer-Reviewed Original ResearchConceptsTumor necrosis factor receptorNecrosis factor receptorTumor necrosis factor receptor-associated factor 1Necrosis factor receptor-associated factor 1Factor receptorPresence of CD3T cell proliferationPeripheral blood leukocytesImmune cell proliferationTranscription factor NF-κBNF-kappaB pathwayFactor NF-κBLymph nodesLymphocyte reactionImmune responseBlood leukocytesNF-κBImmune systemLTbeta receptorTNFR superfamiliesHematologic tissuesCell proliferationFactor 1Hematopoietic tissuesReceptorsB7-H1 costimulation preferentially enhances CD28-independent T-helper cell function
Tamura H, Dong H, Zhu G, Sica G, Flies D, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001, 97: 1809-1816. PMID: 11238124, DOI: 10.1182/blood.v97.6.1809.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenB7-H1 AntigenBlood ProteinsCD28 AntigensCloning, MolecularCytokinesFemaleHumansInducible T-Cell Co-Stimulator LigandLigandsMembrane GlycoproteinsMiceMice, KnockoutMolecular Sequence DataPeptidesProteinsSequence AlignmentT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerConceptsT helper cell functionHuman B7-H1B7-H1T cell proliferationInducible costimulatorT cellsT-lymphocyte antigen-4Cytolytic T cell responsesT cell responsesCell functionGranulocyte-macrophage colony-stimulating factorP815 tumor cellsT cell growthColony-stimulating factorB7-like moleculeAllogeneic antigensLymphocyte responsesInterleukin-10Costimulatory pathwayAntigen-4IL-4Immunologic functionIL-2B7-1Cytokine secretionB7-H3: A costimulatory molecule for T cell activation and IFN-γ production
Chapoval A, Ni J, Lau J, Wilcox R, Flies D, Liu D, Dong H, Sica G, Zhu G, Tamada K, Chen L. B7-H3: A costimulatory molecule for T cell activation and IFN-γ production. Nature Immunology 2001, 2: 269-274. PMID: 11224528, DOI: 10.1038/85339.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigens, CDB7 AntigensB7-1 AntigenCells, CulturedCloning, MolecularCytokinesDendritic CellsHumansInterferon-gammaLymphocyte ActivationMolecular Sequence DataProtein IsoformsReceptors, ImmunologicSequence Homology, Amino AcidT-LymphocytesT-Lymphocytes, CytotoxicTranscription, GeneticTumor Cells, CulturedConceptsIFN-γ productionDendritic cellsB7-H3 proteinT cellsPhorbol myristate acetateB7-H3Inducible costimulatorT-lymphocyte antigen-4Cell-mediated immune responsesPeripheral blood mononuclear cellsAllogeneic T cellsBlood mononuclear cellsInterferon-γ ProductionB7 homolog 3Cytotoxic T cellsB7-H3 mRNAB7 family membersActivated T cellsT cell activationT cell receptor signalingPD-1Cell receptor signalingCostimulatory pathwayInflammatory cytokinesAntigen-4
2000
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
Wang S, Zhu G, Chapoval A, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96: 2808-2813. PMID: 11023515, DOI: 10.1182/blood.v96.8.2808.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAmino Acid SequenceAnimalsAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell DivisionCHO CellsCloning, MolecularCricetinaeCricetulusCTLA-4 AntigenDendritic CellsDNA, ComplementaryGenes, ImmunoglobulinHumansImmunoconjugatesImmunoglobulin GInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInterleukin-10Interleukin-2LigandsLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataProtein Structure, TertiaryProteinsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsB7-H2T cellsMonocyte-derived immature dendritic cellsImmature dendritic cellsIL-10 productionSecretion of interleukinT cell proliferationB7-like moleculeT cell moleculesImmunoglobulin fusion proteinDendritic cellsCell surface expressionCD3 ligationSurface expressionChinese hamster ovary cellsCostimulationHamster ovary cellsCellsOvary cellsPutative ligandCTLA4IgInterleukinCD3Fusion proteinICOSModulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
Tamada K, Shimozaki K, Chapoval A, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu Y, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine 2000, 6: 283-289. PMID: 10700230, DOI: 10.1038/73136.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD18 AntigensCell LineCloning, MolecularGraft vs Host DiseaseGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, CellularInterferon-gammaMembrane ProteinsMiceModels, BiologicalMolecular Sequence DataRecombinant Fusion ProteinsRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionTumor Cells, CulturedTumor Necrosis Factor Ligand Superfamily Member 14Tumor Necrosis Factor-alphaConceptsCo-stimulatory pathwaysTumor necrosis factorT cell-mediated immunityCytolytic T cell responsesT-cell co-stimulatory pathwaysBlockade of LIGHTCell-mediated immunityT cell responsesHost disease modelGranulocyte-macrophage colony-stimulating factorPotential therapeutic targetCo-stimulatory activityT cell growthColony-stimulating factorHost diseaseTherapeutic immunityP815 tumorImmunoregulatory functionsNecrosis factorGamma interferonSoluble receptorTherapeutic targetDisease modelsImmunityGraft
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-1369. PMID: 10581077, DOI: 10.1038/70932.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesB7-H1B7 familyImmune responseT-cell co-stimulatory pathwaysAntigen-specific humoralInterleukin-10 secretionT cell responsesCo-stimulatory moleculesCo-stimulatory pathwaysT cell proliferationAllogeneic antigensInterleukin-10Polyclonal stimuliB7-1Interleukin-2CD28Negative regulationHumoralResponseICOSAntigenSecretion