Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
Tamada K, Shimozaki K, Chapoval A, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu Y, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine 2000, 6: 283-289. PMID: 10700230, DOI: 10.1038/73136.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD18 AntigensCell LineCloning, MolecularGraft vs Host DiseaseGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, CellularInterferon-gammaMembrane ProteinsMiceModels, BiologicalMolecular Sequence DataRecombinant Fusion ProteinsRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionTumor Cells, CulturedTumor Necrosis Factor Ligand Superfamily Member 14Tumor Necrosis Factor-alphaConceptsCo-stimulatory pathwaysTumor necrosis factorT cell-mediated immunityCytolytic T cell responsesT-cell co-stimulatory pathwaysBlockade of LIGHTCell-mediated immunityT cell responsesHost disease modelGranulocyte-macrophage colony-stimulating factorPotential therapeutic targetCo-stimulatory activityT cell growthColony-stimulating factorHost diseaseTherapeutic immunityP815 tumorImmunoregulatory functionsNecrosis factorGamma interferonSoluble receptorTherapeutic targetDisease modelsImmunityGraft