2000
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
Wang S, Zhu G, Chapoval A, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96: 2808-2813. PMID: 11023515, DOI: 10.1182/blood.v96.8.2808.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAmino Acid SequenceAnimalsAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell DivisionCHO CellsCloning, MolecularCricetinaeCricetulusCTLA-4 AntigenDendritic CellsDNA, ComplementaryGenes, ImmunoglobulinHumansImmunoconjugatesImmunoglobulin GInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInterleukin-10Interleukin-2LigandsLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataProtein Structure, TertiaryProteinsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsB7-H2T cellsMonocyte-derived immature dendritic cellsImmature dendritic cellsIL-10 productionSecretion of interleukinT cell proliferationB7-like moleculeT cell moleculesImmunoglobulin fusion proteinDendritic cellsCell surface expressionCD3 ligationSurface expressionChinese hamster ovary cellsCostimulationHamster ovary cellsCellsOvary cellsPutative ligandCTLA4IgInterleukinCD3Fusion proteinICOS
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-1369. PMID: 10581077, DOI: 10.1038/70932.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesB7-H1B7 familyImmune responseT-cell co-stimulatory pathwaysAntigen-specific humoralInterleukin-10 secretionT cell responsesCo-stimulatory moleculesCo-stimulatory pathwaysT cell proliferationAllogeneic antigensInterleukin-10Polyclonal stimuliB7-1Interleukin-2CD28Negative regulationHumoralResponseICOSAntigenSecretion