2001
B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function
Tamura H, Dong H, Zhu G, Sica G, Flies D, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001, 97: 1809-1816. PMID: 11238124, DOI: 10.1182/blood.v97.6.1809.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenB7-H1 AntigenBlood ProteinsCD28 AntigensCloning, MolecularCytokinesFemaleHumansInducible T-Cell Co-Stimulator LigandLigandsMembrane GlycoproteinsMiceMice, KnockoutMolecular Sequence DataPeptidesProteinsSequence AlignmentT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerConceptsT helper cell functionHuman B7-H1B7-H1T cell proliferationInducible costimulatorT cellsT-lymphocyte antigen-4Cytolytic T cell responsesT cell responsesCell functionGranulocyte-macrophage colony-stimulating factorP815 tumor cellsT cell growthColony-stimulating factorB7-like moleculeAllogeneic antigensLymphocyte responsesInterleukin-10Costimulatory pathwayAntigen-4IL-4Immunologic functionIL-2B7-1Cytokine secretion
2000
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
Tamada K, Shimozaki K, Chapoval A, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu Y, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine 2000, 6: 283-289. PMID: 10700230, DOI: 10.1038/73136.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD18 AntigensCell LineCloning, MolecularGraft vs Host DiseaseGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, CellularInterferon-gammaMembrane ProteinsMiceModels, BiologicalMolecular Sequence DataRecombinant Fusion ProteinsRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionTumor Cells, CulturedTumor Necrosis Factor Ligand Superfamily Member 14Tumor Necrosis Factor-alphaConceptsCo-stimulatory pathwaysTumor necrosis factorT cell-mediated immunityCytolytic T cell responsesT-cell co-stimulatory pathwaysBlockade of LIGHTCell-mediated immunityT cell responsesHost disease modelGranulocyte-macrophage colony-stimulating factorPotential therapeutic targetCo-stimulatory activityT cell growthColony-stimulating factorHost diseaseTherapeutic immunityP815 tumorImmunoregulatory functionsNecrosis factorGamma interferonSoluble receptorTherapeutic targetDisease modelsImmunityGraft