2012
The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19)
Yao S, Zhu Y, Zhu G, Augustine M, Goode D, Wang J, Zheng L, Han X, Luo L, Broadwater M, Ruff W, Chen L. The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19). The Journal Of Immunology 2012, 188: 178.19-178.19. DOI: 10.4049/jimmunol.188.supp.178.19.Peer-Reviewed Original ResearchReceptor-ligand interactionsComplex receptor-ligand interactionsHuman transmembrane proteinsKinase-dependent pathwayCell cycle inhibitor p27Kip1High-throughput formatLow expression levelsTransmembrane proteinNon-overlapping domainsTarget proteinsB7-H2Bcl-xLB7-CD28 familyT cellsCell surfaceHematopoietic systemT cell activationExpression levelsHuman T cellsB7-1Potential targetSurvival factor Bcl-xLCD28 costimulationProteinCell activation
2001
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
Chapoval A, Ni J, Lau J, Wilcox R, Flies D, Liu D, Dong H, Sica G, Zhu G, Tamada K, Chen L. B7-H3: A costimulatory molecule for T cell activation and IFN-γ production. Nature Immunology 2001, 2: 269-274. PMID: 11224528, DOI: 10.1038/85339.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigens, CDB7 AntigensB7-1 AntigenCells, CulturedCloning, MolecularCytokinesDendritic CellsHumansInterferon-gammaLymphocyte ActivationMolecular Sequence DataProtein IsoformsReceptors, ImmunologicSequence Homology, Amino AcidT-LymphocytesT-Lymphocytes, CytotoxicTranscription, GeneticTumor Cells, CulturedConceptsIFN-γ productionDendritic cellsB7-H3 proteinT cellsPhorbol myristate acetateB7-H3Inducible costimulatorT-lymphocyte antigen-4Cell-mediated immune responsesPeripheral blood mononuclear cellsAllogeneic T cellsBlood mononuclear cellsInterferon-γ ProductionB7 homolog 3Cytotoxic T cellsB7-H3 mRNAB7 family membersActivated T cellsT cell activationT cell receptor signalingPD-1Cell receptor signalingCostimulatory pathwayInflammatory cytokinesAntigen-4