Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice
Zhu G, Flies D, Tamada K, Sun Y, Rodriguez M, Fu Y, Chen L. Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice. The Journal Of Immunology 2001, 167: 2671-2676. PMID: 11509610, DOI: 10.4049/jimmunol.167.5.2671.Peer-Reviewed Original ResearchMeSH Keywords4-1BB LigandAgingAnimalsAntibody FormationAntigen PresentationAntigens, CDBase SequenceB-LymphocytesDNA, ComplementaryHistocompatibility Antigens Class IIIn Vitro TechniquesLigandsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicPhenotypePromoter Regions, GeneticReceptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorSpleenT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 9Tumor Necrosis Factor-alphaConceptsHumoral immune responseTransgenic miceT cellsImmune responseDefective humoral responseAllogeneic T cellsPeripheral B lymphocytesProgressive splenomegalyCTL responsesHumoral responseAg presentationB cellsB lymphocytesSelective depletionMiceCellsLow levelsProgressive depletionResponseSplenomegalySplenocytesLymphocytesIgGUnexpected function