Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
Wang S, Zhu G, Chapoval A, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96: 2808-2813. PMID: 11023515, DOI: 10.1182/blood.v96.8.2808.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAmino Acid SequenceAnimalsAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell DivisionCHO CellsCloning, MolecularCricetinaeCricetulusCTLA-4 AntigenDendritic CellsDNA, ComplementaryGenes, ImmunoglobulinHumansImmunoconjugatesImmunoglobulin GInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInterleukin-10Interleukin-2LigandsLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataProtein Structure, TertiaryProteinsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsB7-H2T cellsMonocyte-derived immature dendritic cellsImmature dendritic cellsIL-10 productionSecretion of interleukinT cell proliferationB7-like moleculeT cell moleculesImmunoglobulin fusion proteinDendritic cellsCell surface expressionCD3 ligationSurface expressionChinese hamster ovary cellsCostimulationHamster ovary cellsCellsOvary cellsPutative ligandCTLA4IgInterleukinCD3Fusion proteinICOSImmunoglobulin Fusion Proteins as a Tool for Evaluation of T-Cell Costimulatory Molecules
Chapoval A, Zhu G, Chen L. Immunoglobulin Fusion Proteins as a Tool for Evaluation of T-Cell Costimulatory Molecules. Methods In Molecular Medicine 2000, 45: 247-255. PMID: 21341062, DOI: 10.1385/1-59259-079-9:247.Peer-Reviewed Original ResearchCostimulatory moleculesT cell receptorT cell costimulatory moleculesWeak tumor antigensT lymphocyte activationPeptide-major histocompatibility complexImmunoglobulin fusion proteinPoor immunogenicityLack of expressionImmune responseTumor antigensAccessory signalsImmune systemHistocompatibility complexRecent studiesFusion proteinImmunogenicityAntigenReceptors