2001
Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice
Zhu G, Flies D, Tamada K, Sun Y, Rodriguez M, Fu Y, Chen L. Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice. The Journal Of Immunology 2001, 167: 2671-2676. PMID: 11509610, DOI: 10.4049/jimmunol.167.5.2671.Peer-Reviewed Original ResearchMeSH Keywords4-1BB LigandAgingAnimalsAntibody FormationAntigen PresentationAntigens, CDBase SequenceB-LymphocytesDNA, ComplementaryHistocompatibility Antigens Class IIIn Vitro TechniquesLigandsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicPhenotypePromoter Regions, GeneticReceptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorSpleenT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 9Tumor Necrosis Factor-alphaConceptsHumoral immune responseTransgenic miceT cellsImmune responseDefective humoral responseAllogeneic T cellsPeripheral B lymphocytesProgressive splenomegalyCTL responsesHumoral responseAg presentationB cellsB lymphocytesSelective depletionMiceCellsLow levelsProgressive depletionResponseSplenomegalySplenocytesLymphocytesIgGUnexpected functionRELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB
Sica G, Zhu G, Tamada K, Liu D, Ni J, Chen L. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB. Blood 2001, 97: 2702-2707. PMID: 11313261, DOI: 10.1182/blood.v97.9.2702.Peer-Reviewed Original ResearchConceptsTumor necrosis factor receptorNecrosis factor receptorTumor necrosis factor receptor-associated factor 1Necrosis factor receptor-associated factor 1Factor receptorPresence of CD3T cell proliferationPeripheral blood leukocytesImmune cell proliferationTranscription factor NF-κBNF-kappaB pathwayFactor NF-κBLymph nodesLymphocyte reactionImmune responseBlood leukocytesNF-κBImmune systemLTbeta receptorTNFR superfamiliesHematologic tissuesCell proliferationFactor 1Hematopoietic tissuesReceptors
2000
Immunoglobulin Fusion Proteins as a Tool for Evaluation of T-Cell Costimulatory Molecules
Chapoval A, Zhu G, Chen L. Immunoglobulin Fusion Proteins as a Tool for Evaluation of T-Cell Costimulatory Molecules. Methods In Molecular Medicine 2000, 45: 247-255. PMID: 21341062, DOI: 10.1385/1-59259-079-9:247.Peer-Reviewed Original ResearchCostimulatory moleculesT cell receptorT cell costimulatory moleculesWeak tumor antigensT lymphocyte activationPeptide-major histocompatibility complexImmunoglobulin fusion proteinPoor immunogenicityLack of expressionImmune responseTumor antigensAccessory signalsImmune systemHistocompatibility complexRecent studiesFusion proteinImmunogenicityAntigenReceptors
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-1369. PMID: 10581077, DOI: 10.1038/70932.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesB7-H1B7 familyImmune responseT-cell co-stimulatory pathwaysAntigen-specific humoralInterleukin-10 secretionT cell responsesCo-stimulatory moleculesCo-stimulatory pathwaysT cell proliferationAllogeneic antigensInterleukin-10Polyclonal stimuliB7-1Interleukin-2CD28Negative regulationHumoralResponseICOSAntigenSecretion