2000
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
Tamada K, Shimozaki K, Chapoval A, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu Y, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine 2000, 6: 283-289. PMID: 10700230, DOI: 10.1038/73136.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD18 AntigensCell LineCloning, MolecularGraft vs Host DiseaseGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, CellularInterferon-gammaMembrane ProteinsMiceModels, BiologicalMolecular Sequence DataRecombinant Fusion ProteinsRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionTumor Cells, CulturedTumor Necrosis Factor Ligand Superfamily Member 14Tumor Necrosis Factor-alphaConceptsCo-stimulatory pathwaysTumor necrosis factorT cell-mediated immunityCytolytic T cell responsesT-cell co-stimulatory pathwaysBlockade of LIGHTCell-mediated immunityT cell responsesHost disease modelGranulocyte-macrophage colony-stimulating factorPotential therapeutic targetCo-stimulatory activityT cell growthColony-stimulating factorHost diseaseTherapeutic immunityP815 tumorImmunoregulatory functionsNecrosis factorGamma interferonSoluble receptorTherapeutic targetDisease modelsImmunityGraft
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-1369. PMID: 10581077, DOI: 10.1038/70932.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesB7-H1B7 familyImmune responseT-cell co-stimulatory pathwaysAntigen-specific humoralInterleukin-10 secretionT cell responsesCo-stimulatory moleculesCo-stimulatory pathwaysT cell proliferationAllogeneic antigensInterleukin-10Polyclonal stimuliB7-1Interleukin-2CD28Negative regulationHumoralResponseICOSAntigenSecretion