2012
The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19)
Yao S, Zhu Y, Zhu G, Augustine M, Goode D, Wang J, Zheng L, Han X, Luo L, Broadwater M, Ruff W, Chen L. The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19). The Journal Of Immunology 2012, 188: 178.19-178.19. DOI: 10.4049/jimmunol.188.supp.178.19.Peer-Reviewed Original ResearchReceptor-ligand interactionsComplex receptor-ligand interactionsHuman transmembrane proteinsKinase-dependent pathwayCell cycle inhibitor p27Kip1High-throughput formatLow expression levelsTransmembrane proteinNon-overlapping domainsTarget proteinsB7-H2Bcl-xLB7-CD28 familyT cellsCell surfaceHematopoietic systemT cell activationExpression levelsHuman T cellsB7-1Potential targetSurvival factor Bcl-xLCD28 costimulationProteinCell activation
2000
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
Wang S, Zhu G, Chapoval A, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96: 2808-2813. PMID: 11023515, DOI: 10.1182/blood.v96.8.2808.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAmino Acid SequenceAnimalsAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell DivisionCHO CellsCloning, MolecularCricetinaeCricetulusCTLA-4 AntigenDendritic CellsDNA, ComplementaryGenes, ImmunoglobulinHumansImmunoconjugatesImmunoglobulin GInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInterleukin-10Interleukin-2LigandsLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataProtein Structure, TertiaryProteinsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsB7-H2T cellsMonocyte-derived immature dendritic cellsImmature dendritic cellsIL-10 productionSecretion of interleukinT cell proliferationB7-like moleculeT cell moleculesImmunoglobulin fusion proteinDendritic cellsCell surface expressionCD3 ligationSurface expressionChinese hamster ovary cellsCostimulationHamster ovary cellsCellsOvary cellsPutative ligandCTLA4IgInterleukinCD3Fusion proteinICOS