2012
The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19)
Yao S, Zhu Y, Zhu G, Augustine M, Goode D, Wang J, Zheng L, Han X, Luo L, Broadwater M, Ruff W, Chen L. The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19). The Journal Of Immunology 2012, 188: 178.19-178.19. DOI: 10.4049/jimmunol.188.supp.178.19.Peer-Reviewed Original ResearchReceptor-ligand interactionsComplex receptor-ligand interactionsHuman transmembrane proteinsKinase-dependent pathwayCell cycle inhibitor p27Kip1High-throughput formatLow expression levelsTransmembrane proteinNon-overlapping domainsTarget proteinsB7-H2Bcl-xLB7-CD28 familyT cellsCell surfaceHematopoietic systemT cell activationExpression levelsHuman T cellsB7-1Potential targetSurvival factor Bcl-xLCD28 costimulationProteinCell activation
2001
B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function
Tamura H, Dong H, Zhu G, Sica G, Flies D, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001, 97: 1809-1816. PMID: 11238124, DOI: 10.1182/blood.v97.6.1809.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenB7-H1 AntigenBlood ProteinsCD28 AntigensCloning, MolecularCytokinesFemaleHumansInducible T-Cell Co-Stimulator LigandLigandsMembrane GlycoproteinsMiceMice, KnockoutMolecular Sequence DataPeptidesProteinsSequence AlignmentT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerConceptsT helper cell functionHuman B7-H1B7-H1T cell proliferationInducible costimulatorT cellsT-lymphocyte antigen-4Cytolytic T cell responsesT cell responsesCell functionGranulocyte-macrophage colony-stimulating factorP815 tumor cellsT cell growthColony-stimulating factorB7-like moleculeAllogeneic antigensLymphocyte responsesInterleukin-10Costimulatory pathwayAntigen-4IL-4Immunologic functionIL-2B7-1Cytokine secretion
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-1369. PMID: 10581077, DOI: 10.1038/70932.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesB7-H1B7 familyImmune responseT-cell co-stimulatory pathwaysAntigen-specific humoralInterleukin-10 secretionT cell responsesCo-stimulatory moleculesCo-stimulatory pathwaysT cell proliferationAllogeneic antigensInterleukin-10Polyclonal stimuliB7-1Interleukin-2CD28Negative regulationHumoralResponseICOSAntigenSecretion