2002
Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia.
Shi CQ, Young LH, Daher E, DiBella EV, Liu YH, Heller EN, Zoghbi S, Wackers FJ, Soufer R, Sinusas AJ. Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia. Journal Of Nuclear Medicine 2002, 43: 421-31. PMID: 11884504.Peer-Reviewed Original Research
2000
Reproducibility and accuracy of gated SPECT for determination of left ventricular volumes and ejection fraction: experimental validation using MRI.
Vallejo E, Dione DP, Bruni WL, Constable RT, Borek PP, Soares JP, Carr JG, Condos SG, Wackers FJ, Sinusas AJ. Reproducibility and accuracy of gated SPECT for determination of left ventricular volumes and ejection fraction: experimental validation using MRI. Journal Of Nuclear Medicine 2000, 41: 874-82; discussion 883-6. PMID: 10809204.Peer-Reviewed Original Research
1998
Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging.
Wu JC, Yun JJ, Heller EN, Dione DP, DeMan P, Liu YH, Zaret BL, Wackers FJ, Sinusas AJ. Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. Journal Of Nuclear Medicine 1998, 39: 417-25. PMID: 9529285.Peer-Reviewed Original ResearchConceptsSingle-vessel stenosisMyocardial blood flowDobutamine stressCoronary stenosisTechnetium-99mBlood flowLeft circumflex artery stenosisCircumflex artery stenosisFlow deficitsSingle coronary stenosisCoronary artery diseaseRate-pressure productRegional myocardial blood flowLeft ventricular pressurePeak dobutamine stressOpen-chest dogsNonischemic flowArtery diseaseArtery stenosisPeak dobutamineSestamibi activitySevere stenosisVentricular pressureSestamibi imagingIschemic zone
1996
Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model
Liu Y, Sinusas A, Shi C, Shen M, Dione D, Heller E, Wackers F. Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model. Journal Of Nuclear Cardiology 1996, 3: 312-320. PMID: 8799250, DOI: 10.1016/s1071-3581(96)90091-4.Peer-Reviewed Original ResearchConceptsMyocardial blood flowRelative blood flowRelative myocardial blood flowRegional myocardial blood flowCoronary artery occlusionBlood flowSingle photon emissionArtery occlusionCanine modelShort-axis slicesEx vivoSestamibi single-photon emissionMyocardial countsFlow deficitsMyocardial count densityNormal blood flowMean countsRegional myocardial perfusionCount profilesMIBI uptakeMIBI SPECTSestamibi SPECTMyocardial perfusionCircumferential count profilesRelative regional myocardial blood flow
1995
Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia.
Shi CQ, Sinusas AJ, Dione DP, Singer MJ, Young LH, Heller EN, Rinker BD, Wackers FJ, Zaret BL. Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. Journal Of Nuclear Medicine 1995, 36: 1078-86. PMID: 7769431.Peer-Reviewed Original ResearchConceptsIschemic regionMyocardial ischemiaBlood flowEx vivo SPECTRegional myocardial blood flowPartial coronary occlusionMicrosphere blood flowMyocardial blood flowOpen-chest canine modelVivo SPECT imagesSPECT imagesVivo planarCentral ischemic regionCoronary occlusionDemand ischemiaBMS181321Technetium-99mIntravenous injectionLiver ratioMyocardial imagingCanine modelPositive imagingHepatic clearanceLiver activityArterial sampling
1994
Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia.
Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. Journal Of Nuclear Medicine 1994, 35: 664-71. PMID: 8151391.Peer-Reviewed Original ResearchConceptsTechnetium-99mCanine modelPerfusion tracerMicrosphere flowCoronary artery occlusionInitial myocardial uptakeIntact canine modelOpen-chest dogsMyocardial perfusion imagingMyocardial blood flowDynamic planar imagingArtery occlusionPharmacological vasodilatationPharmacological stressMyocardial perfusion tracersMyocardial uptakeRadiotracer injectionBlood flowMyocardial perfusionPerfusion imagingArterial samplingMyocardial flowBackground activity ratioTetrofosminIschemia
1993
Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size.
Sinusas AJ, Shi Q, Vitols PJ, Fetterman RC, Maniawski P, Zaret BL, Wackers FJ. Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size. Circulation 1993, 88: 2224-2234. PMID: 8222117, DOI: 10.1161/01.cir.88.5.2224.Peer-Reviewed Original ResearchConceptsHours of reperfusionDobutamine stressMyocardial thickeningVentricular geometryDefect magnitudeCoronary artery occlusionLeft ventricular geometryOpen-chest dogsRegional ventricular functionCircumferential profile analysisDefect sizeMIBI defectsArtery occlusionMyocardial salvageVentricular functionVentricular sizePharmacological stressNonviable myocardiumES imagesMyocardial perfusionInfarcted dogsRegional functionReperfusionRisk areasDogsNuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. New England Journal Of Medicine 1993, 329: 855-863. PMID: 8355745, DOI: 10.1056/nejm199309163291208.Peer-Reviewed Original Research
1982
Gold-195m, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography
Wackers F, Giles R, Hoffer P, Lange R, Berger H, Zaret B, Pytlik L, Plankey M. Gold-195m, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography. The American Journal Of Cardiology 1982, 50: 89-94. PMID: 7046410, DOI: 10.1016/0002-9149(82)90013-3.Peer-Reviewed Original Research
1981
Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model.
Wackers F, Klay J, Laks H, Schnitzer J, Zaret B, Geha A. Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model. Circulation 1981, 64: 1256-1264. PMID: 6457702, DOI: 10.1161/01.cir.64.6.1256.Peer-Reviewed Original ResearchRadionuclide assessment of peripheral intravascular capacity: a technique to measure intravascular volume changes in the capacitance circulation in man.
Rutlen D, Wackers F, Zaret B. Radionuclide assessment of peripheral intravascular capacity: a technique to measure intravascular volume changes in the capacitance circulation in man. Circulation 1981, 64: 146-152. PMID: 6786793, DOI: 10.1161/01.cir.64.1.146.Peer-Reviewed Original ResearchConceptsCapacitance vasculatureVascular capacityIntravascular spaceIntegrated cardiovascular functionIntravascular volume changesGamma camera imagingVenous returnLeg elevationSublingual nitroglycerinVentricular performanceContralateral forearmCardiovascular functionCardiac performanceRadionuclide assessmentBlood volumeRadionuclide imagingPathophysiologic statesPatientsCardiac imagingTwo minutesForearmMenNitroglycerinCountVasculature
1980
Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia
Wackers F. Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia. Seminars In Nuclear Medicine 1980, 10: 127-145. PMID: 7394537, DOI: 10.1016/s0001-2998(80)80016-x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionPerfusion defectsThallium-201 myocardial scintigraphyThallium-201 scintigraphyOnset of symptomsResults of scintigraphyChest painUnstable anginaJeopardized myocardiumMyocardial scintigraphyPrognostic stratificationEarly recognitionHigh riskInfarctionPatientsScintigraphyIschemiaHrAnginaComplicationsPainReliable method
1975
Noninvasive visualization of acute myocardial infarction in man with thallium-201.
Wackers F, Schoot J, Sokole E, Samson G, Niftrik G, Lie K, Durrer D, Wellens H. Noninvasive visualization of acute myocardial infarction in man with thallium-201. Heart 1975, 37: 741. PMID: 1156481, PMCID: PMC482866, DOI: 10.1136/hrt.37.7.741.Peer-Reviewed Original Research