Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation
Cheng FY, Huang X, Sarangi A, Ketova T, Cooper MK, Litingtung Y, Chiang C. Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation. PLOS ONE 2012, 7: e35541. PMID: 22539980, PMCID: PMC3335071, DOI: 10.1371/journal.pone.0035541.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic ProteinsCell LineageCerebellumGrowth Differentiation FactorsHedgehog ProteinsHyperplasiaMedulloblastomaMiceNeurogliaNeuronsSignal TransductionTumor Cells, CulturedConceptsSonic hedgehog-driven medulloblastomaGlutamatergic granule neuronsBergmann glial cellsCentral nervous systemChoroid plexus epithelial cellsCell typesGenetic fate-mapping studiesGlial cell typesChoroid plexus epitheliumUnipolar brush cellsCerebellar granule neuron precursorsPlexus epithelial cellsGranule neuron precursorsGABAergic interneuronsNeural cell typesGlial cellsPurkinje neuronsNervous systemGranule neuronsRoof plateWhite matterPlexus epitheliumBrush cellsNeuron precursorsSonic hedgehog (Shh) signaling